{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:09:14Z","timestamp":1766182154171},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vasomotion is the oscillation of vascular tone which gives rise to flow motion of blood into an organ. As is well known, spontaneous contractile organs such as heart, GI, and genitourinary tract produce rhythmic contraction. It imposes or removes pressure on their vessels alternatively for exchange of many substances. It was first described over 150 years ago, however the physiological mechanism and pathophysiological implications are not well understood. This study aimed to elucidate underlying mechanisms and physiological function of vasomotion in human arteries. Conventional contractile force measurement, immunohistochemistry, and Western blot analysis were employed to study human left gastric artery (HLGA) and uterine arteries (HUA). RESULTS: Circular muscle of HLGA and\/or HUA produced sustained tonic contraction by high K<jats:sup>+<\/jats:sup> (50\u2009mM) which was blocked by 2\u2009\u00b5M nifedipine. Stepwise stretch and high K<jats:sup>+<\/jats:sup> produced nerve\u2010independent spontaneous contraction (vasomotion) (around 45% of tested tissues). Vasomotion was also produced by application of BayK\u00a08644, 5\u2010HT, prostagrandins, oxytocin. It was blocked by nifedipine (2\u2009\u00b5M) and blockers of intracellular Ca<jats:sup>2+<\/jats:sup> stores. Inhibitors of Ca<jats:sup>2+<\/jats:sup>\u2010activated Cl<jats:sup>\u2212<\/jats:sup> channels (DIDS and\/or niflumic acid) and ATP\u2010sensitive K<jats:sup>+<\/jats:sup> (K<jats:sub>ATP<\/jats:sub>) channels inhibited vasomotion reversibly. Metabolic inhibition by sodium cyanide (NaCN) and several neuropeptides also regulated vasomotion in K<jats:sub>ATP<\/jats:sub> channel\u2010sensitive and \u2010insensitive manner. Finally, we identified TMEM16A Ca<jats:sup>2+<\/jats:sup>\u2010activated Cl<jats:sup>\u2212<\/jats:sup> channels and subunits of K<jats:sub>ATP<\/jats:sub> channels (Kir 6.1\/6.2 and sulfonylurea receptor 2B [SUR2B]), and c\u2010<jats:italic>Kit<\/jats:italic> positivity by Western blot analysis. We conclude that vasomotion is sensitive to TMEM16A Ca<jats:sup>2+<\/jats:sup>\u2010activated Cl<jats:sup>\u2212<\/jats:sup> channels and metabolic changes in human gastric and uterine arteries. Vasomotion might play an important role in the regulation of microcirculation dynamics even in pacemaker\u2010related autonomic contractile organs in humans.<\/jats:p>","DOI":"10.1002\/jcp.31067","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:10:00Z","timestamp":1694020200000},"page":"2076-2089","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vasomotion in human arteries and their regulations based on ion channel regulations: 10 years study"],"prefix":"10.1002","volume":"238","author":[{"given":"Dae Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, Chungbuk National University Hospital (CBNUH) Chungbuk National University (CBNU) Cheongju Chungbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of OBGY, College of Medicine, CBNU College of Medicine, CBNU, (CBNUH) Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of OBGY, College of Medicine, CBNU College of Medicine, CBNU, (CBNUH) Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Myoung","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song\u2010Yi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Chungnam National University Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beommo","family":"Koo","sequence":"additional","affiliation":[{"name":"College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheong\u2010Sil","family":"Rah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uijeongbu Eulji Medical Center Eulji University Uijeongbu\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyun","family":"Nam","sequence":"additional","affiliation":[{"name":"College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Jin","family":"Ju","sequence":"additional","affiliation":[{"name":"College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra Young","family":"You","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of OBGY, College of Medicine, CBNU College of Medicine, CBNU, (CBNUH) Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, CBNU &amp; CBNUH Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang\u2010Whan","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, CBNU &amp; CBNUH Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hun Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Xie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department\u00a0of Physiology, College of Medcine Shanghai Jiaotong University Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Medicine, CBNU Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo\u2010Yung","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Chungbuk National University Hospital (CBNUH) Chungbuk National University (CBNU) Cheongju Chungbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2011.02320.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706084"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0532-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0037rev"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00422"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.018796"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.29531"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2018.01.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.4.H1696"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.086405"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2015.06.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000143014.04535.a3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00352.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2015.06.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.6.4.579"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/373347a0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.54.345"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000499981.55788.a6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.1.42"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1540\/jsmr.56.29"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15616138"},{"issue":"10","key":"e_1_2_11_23_1","article-title":"Mechanisms of cellular synchronization in the vascular wall. 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