{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:05:37Z","timestamp":1788869137348,"version":"build-2803163510"},"reference-count":132,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Starch\u2010binding domain\u2010containing protein 1 (STBD1) is a glycogen\u2010binding protein discovered in skeletal muscle gene differential expression that is pivotal to cellular energy metabolism. Recent studies have indicated that STBD1 is involved in many physiological processes, such as glycophagy, glycogen accumulation, and lipid droplet formation. Moreover, dysregulation of STBD1 causes multiple diseases, including cardiovascular disease, metabolic disease, and even cancer. Deletions and\/or mutations in STBD1 promote tumorigenesis. Therefore, STBD1 has garnered considerable interest in the pathology community. In this review, we first summarized the current understanding of STBD1, including its structure, subcellular localization, tissue distribution, and biological functions. Next, we examined the roles and molecular mechanisms of STBD1 in related diseases. Based on available research, we discussed the novel function and future of STBD1, including its potential application as a therapeutic target in glycogen\u2010related diseases. Given the significance of STBD1 in energy metabolism, an in\u2010depth understanding of the protein is crucial for understanding physiological processes and developing therapeutic strategies for related diseases.<\/jats:p>","DOI":"10.1002\/jcp.31078","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T10:58:10Z","timestamp":1689159490000},"page":"2010-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Glycogen\u2010binding protein STBD1: Molecule and role in pathophysiology"],"prefix":"10.1002","volume":"238","author":[{"given":"Qiannan","family":"Tang","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology Hengyang Medical School, University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Diseases of Yunnan Province, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province Central Laboratory of Yan'an Hospital Affiliated to Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nursing College, Hengyang Medical School University of South China Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-1089","authenticated-orcid":false,"given":"Linxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology Hengyang Medical School, University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja062999h"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim200127"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28833"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3735"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101156"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.1.189"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.10.2949"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3350549"},{"key":"e_1_2_11_10_1","first-page":"1098","article-title":"Effects of 2\u2010deoxyglucose on carbohydrate metablism: Review of the literature and studies in the rat","volume":"11","author":"Brown J.","year":"1962","journal-title":"Metabolism: Clinical and Experimental"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.037"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.25498"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12370"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.592129"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006819"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.189"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07221.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7090133"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/206201b0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00002.2015"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.195263"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3053"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.02.001"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0120"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113382"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-5-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.03.008"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102339"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100042200"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1157"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.302.1.111"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1121"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1310265"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008862"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22499"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.217364"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11910"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002237"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23539-5"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0860011"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3270"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.034"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.5.3.272"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21238974"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002142"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13884"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.11.1534"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.07.009"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.150839"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.08.106"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.14670\/HH-14.23"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.14670\/HH-15.1011"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10104"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.149740"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20515"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1565707"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4024"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.14670\/HH-20.689"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20046"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2006.04.001"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1723"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0910-836"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11262"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0078"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2022.06.003"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90515-0"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.1.E184"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.639427"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2005.8.3"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49860"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1138-4"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baaa045"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606547"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.12.027"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2006.11.012"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.11.023"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.02.013"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.244855"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.171"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13148"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.616714"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1545107"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-020-02979-6"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.073"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10091339"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.10.17148"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00059.2014"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6408com"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744738"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.4.6.685"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.01.018"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5320(71)80121-1"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2104-y"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28195"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61555-X"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064093"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00763-9"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2003.08.022"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.8.13378"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.09.014"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.8.3.575"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111416"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.12.014"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.485"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071165"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.024406"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00249.2019"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.487"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076133"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2979"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C116.741397"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.818237"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0301-2"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00271.2020"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1751"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.10.035"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.152"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1021831621210"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109337"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.10.16740"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.08.015"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.23.33"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0480-9"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.05.004"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2016.52.1.1"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add2696"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1939972"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.06.014"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20140053"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322563111"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.31078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T21:23:02Z","timestamp":1700083382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.31078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,12]]},"references-count":132,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/jcp.31078"],"URL":"https:\/\/doi.org\/10.1002\/jcp.31078","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,12]]},"assertion":[{"value":"2023-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}