{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:18:30Z","timestamp":1740104310399,"version":"3.37.3"},"reference-count":81,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adolescent idiopathic scoliosis (AIS) is a common spinal deformity in young women, but its pathogenesis remains unclear. The primary pathogenic factors contributing to its development include genetics, abnormal bone metabolism, and endocrine factors. Bone marrow stem cells (BMSCs) play a crucial role in the pathogenesis of AIS by regulating its occurrence and progression. Noncoding RNAs (ncRNAs) are also involved in the pathogenesis of AIS, and their role in regulating BMSCs in patients with AIS requires further evaluation. In this review, we discuss the relevant literature regarding the osteogenic, chondrogenic, and lipogenic differentiation of BMSCs. The corresponding mechanisms of ncRNA\u2010mediated BMSC regulation in patients with AIS, recent advancements in AIS and ncRNA research, and the importance of ncRNA translation profiling and multiomics are highlighted.<\/jats:p>","DOI":"10.1002\/jcp.31119","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T17:38:05Z","timestamp":1694194685000},"page":"2228-2242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on the regulation of bone marrow stem cells by noncoding RNAs in adolescent idiopathic scoliosis"],"prefix":"10.1002","volume":"238","author":[{"given":"Meng\u2010Jun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Spine Surgery and Orthopedics Xiangya Hospital, Central South University Changsha Hunan P.R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo\u2010Tao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery and Orthopedics Xiangya Hospital, Central South University Changsha Hunan P.R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery and Orthopedics Xiangya Hospital, Central South University Changsha Hunan P.R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery and Orthopedics Xiangya Hospital, Central South University Changsha Hunan P.R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery and Orthopedics Xiangya Hospital, Central South University Changsha Hunan P.R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-620X","authenticated-orcid":false,"given":"Ang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery and Orthopedics Xiangya Hospital, Central South University Changsha Hunan P.R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1016\/j.diff.2016.02.005"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1186\/s13287-015-0225-8"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1242\/dev.152504"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1016\/j.omtn.2020.12.003"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.3390\/cells8050477"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1038\/s41598-022-12938-3"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"1513","article-title":"MicroRNA\u2011223 promotes osteoblast differentiation of MC3T3\u2011E1 cells by targeting histone deacetylase 2","volume":"43","author":"Chen J.","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1186\/s10020-021-00326-y"},{"key":"e_1_2_9_10_1","first-page":"23","article-title":"Lower WNT16 expression in patients with adolescent idiopathic scoliosis\u2014potential link to lower bone mass in AIS?","volume":"280","author":"Cheng K. L.","year":"2021","journal-title":"Studies in Health and Technology Informatics"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1007\/s13105-016-0468-6"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1038\/s41413-022-00239-4"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1016\/j.yexcr.2016.07.010"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1038\/s41598-018-21146-x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.1002\/jsp2.1016"},{"doi-asserted-by":"publisher","key":"e_1_2_9_16_1","DOI":"10.1371\/journal.pone.0091354"},{"doi-asserted-by":"publisher","key":"e_1_2_9_17_1","DOI":"10.18632\/aging.203267"},{"doi-asserted-by":"publisher","key":"e_1_2_9_18_1","DOI":"10.1016\/j.mehy.2019.03.024"},{"doi-asserted-by":"publisher","key":"e_1_2_9_19_1","DOI":"10.1111\/os.12694"},{"doi-asserted-by":"publisher","key":"e_1_2_9_20_1","DOI":"10.1016\/j.omtn.2019.08.027"},{"doi-asserted-by":"publisher","key":"e_1_2_9_21_1","DOI":"10.1016\/j.spinee.2019.05.003"},{"doi-asserted-by":"publisher","key":"e_1_2_9_22_1","DOI":"10.1186\/s10020-018-0049-y"},{"doi-asserted-by":"publisher","key":"e_1_2_9_23_1","DOI":"10.1093\/hmg\/ddv170"},{"doi-asserted-by":"publisher","key":"e_1_2_9_24_1","DOI":"10.1007\/s11832-012-0457-4"},{"doi-asserted-by":"publisher","key":"e_1_2_9_25_1","DOI":"10.1007\/s00198-005-1964-7"},{"doi-asserted-by":"publisher","key":"e_1_2_9_26_1","DOI":"10.1172\/JCI99044"},{"doi-asserted-by":"publisher","key":"e_1_2_9_27_1","DOI":"10.1016\/j.scr.2012.11.007"},{"doi-asserted-by":"publisher","key":"e_1_2_9_28_1","DOI":"10.3389\/fmed.2020.583243"},{"doi-asserted-by":"publisher","key":"e_1_2_9_29_1","DOI":"10.1038\/s41419-019-1949-7"},{"doi-asserted-by":"publisher","key":"e_1_2_9_30_1","DOI":"10.1186\/s13148-019-0706-1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_31_1","DOI":"10.1002\/jcb.25927"},{"doi-asserted-by":"publisher","key":"e_1_2_9_32_1","DOI":"10.1111\/cpr.12736"},{"doi-asserted-by":"publisher","key":"e_1_2_9_33_1","DOI":"10.3892\/mmr.2021.12428"},{"doi-asserted-by":"publisher","key":"e_1_2_9_34_1","DOI":"10.1038\/nrendo.2011.234"},{"doi-asserted-by":"publisher","key":"e_1_2_9_35_1","DOI":"10.1371\/journal.pone.0036648"},{"doi-asserted-by":"publisher","key":"e_1_2_9_36_1","DOI":"10.18632\/oncotarget.18655"},{"doi-asserted-by":"publisher","key":"e_1_2_9_37_1","DOI":"10.1097\/BRS.0000000000002111"},{"doi-asserted-by":"publisher","key":"e_1_2_9_38_1","DOI":"10.1007\/s11010-014-1963-0"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/276049","article-title":"Expression signatures of long noncoding RNAs in adolescent idiopathic scoliosis","volume":"2015","author":"Liu X. Y.","year":"2015","journal-title":"BioMed Research International"},{"doi-asserted-by":"publisher","key":"e_1_2_9_40_1","DOI":"10.1186\/s13018-019-1505-2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_41_1","DOI":"10.3390\/jpm12111925"},{"doi-asserted-by":"publisher","key":"e_1_2_9_42_1","DOI":"10.1016\/j.bbrc.2017.04.090"},{"doi-asserted-by":"publisher","key":"e_1_2_9_43_1","DOI":"10.7150\/thno.24677"},{"doi-asserted-by":"publisher","key":"e_1_2_9_44_1","DOI":"10.1007\/s00586-009-1129-z"},{"doi-asserted-by":"publisher","key":"e_1_2_9_45_1","DOI":"10.1097\/CM9.0000000000000652"},{"doi-asserted-by":"publisher","key":"e_1_2_9_46_1","DOI":"10.1016\/j.bone.2018.05.019"},{"doi-asserted-by":"publisher","key":"e_1_2_9_47_1","DOI":"10.1128\/MCB.24.8.3505-3513.2004"},{"issue":"9","key":"e_1_2_9_48_1","first-page":"268","article-title":"[Pulmonary function in adolescents with idiopathic thoracic scoliosis before and after surgical correction]","volume":"115","author":"Saki\u0107 K.","year":"1993","journal-title":"Lijecnicki Vjesnik"},{"doi-asserted-by":"publisher","key":"e_1_2_9_49_1","DOI":"10.1002\/jcb.25631"},{"doi-asserted-by":"publisher","key":"e_1_2_9_50_1","DOI":"10.1097\/BRS.0b013e31829e0956"},{"doi-asserted-by":"publisher","key":"e_1_2_9_51_1","DOI":"10.1242\/dev.193409"},{"doi-asserted-by":"publisher","key":"e_1_2_9_52_1","DOI":"10.1016\/j.molcel.2021.08.033"},{"doi-asserted-by":"publisher","key":"e_1_2_9_53_1","DOI":"10.1002\/jcp.25920"},{"issue":"8","key":"e_1_2_9_54_1","first-page":"4746","article-title":"Downregulation of microRNA\u201016\u20105p accelerates fracture healing by promoting proliferation and inhibiting apoptosis of osteoblasts in patients with traumatic brain injury","volume":"11","author":"Sun Y.","year":"2019","journal-title":"American Journal of Translational Research"},{"doi-asserted-by":"publisher","key":"e_1_2_9_55_1","DOI":"10.1186\/s13578-021-00601-9"},{"doi-asserted-by":"publisher","key":"e_1_2_9_56_1","DOI":"10.1038\/ng.974"},{"doi-asserted-by":"publisher","key":"e_1_2_9_57_1","DOI":"10.18632\/aging.102106"},{"doi-asserted-by":"publisher","key":"e_1_2_9_58_1","DOI":"10.3892\/mmr.2016.5109"},{"doi-asserted-by":"publisher","key":"e_1_2_9_59_1","DOI":"10.1186\/s13287-020-02105-8"},{"key":"e_1_2_9_60_1","first-page":"1","article-title":"Dysregulated bone metabolism is related to high expression of miR\u2010151a\u20103p in severe adolescent idiopathic scoliosis","volume":"2020","author":"Wang Y.","year":"2020","journal-title":"BioMed Research International"},{"doi-asserted-by":"publisher","key":"e_1_2_9_61_1","DOI":"10.1186\/s12920-021-00889-z"},{"doi-asserted-by":"publisher","key":"e_1_2_9_62_1","DOI":"10.1002\/jbmr.3871"},{"issue":"10","key":"e_1_2_9_63_1","first-page":"1288","article-title":"[miR\u201093\u20105P suppresses osteogenic differentiation of mouse C3H10T1\/2 cells by targeting Smad5]","volume":"29","author":"Xu L.","year":"2015","journal-title":"Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery"},{"doi-asserted-by":"publisher","key":"e_1_2_9_64_1","DOI":"10.1002\/jcb.29709"},{"doi-asserted-by":"publisher","key":"e_1_2_9_65_1","DOI":"10.1080\/03008207.2021.2019247"},{"doi-asserted-by":"publisher","key":"e_1_2_9_66_1","DOI":"10.1093\/jnci\/djx166"},{"doi-asserted-by":"publisher","key":"e_1_2_9_67_1","DOI":"10.1002\/jsp2.1184"},{"doi-asserted-by":"publisher","key":"e_1_2_9_68_1","DOI":"10.1186\/s12891-022-05561-w"},{"doi-asserted-by":"publisher","key":"e_1_2_9_69_1","DOI":"10.18632\/aging.204381"},{"doi-asserted-by":"publisher","key":"e_1_2_9_70_1","DOI":"10.1111\/acel.13114"},{"key":"e_1_2_9_71_1","article-title":"Aberrant miR\u2010145\u20105p\/\u03b2\u2010catenin signal impairs osteocyte function in adolescent idiopathic scoliosis","volume":"32","author":"Zhang J.","year":"2018","journal-title":"FASEB Journal"},{"doi-asserted-by":"publisher","key":"e_1_2_9_72_1","DOI":"10.1002\/pmic.201500005"},{"doi-asserted-by":"publisher","key":"e_1_2_9_73_1","DOI":"10.1089\/dna.2016.3544"},{"doi-asserted-by":"publisher","key":"e_1_2_9_74_1","DOI":"10.1016\/j.gene.2022.146199"},{"doi-asserted-by":"publisher","key":"e_1_2_9_75_1","DOI":"10.1371\/journal.pone.0182678"},{"doi-asserted-by":"publisher","key":"e_1_2_9_76_1","DOI":"10.18632\/aging.102583"},{"doi-asserted-by":"publisher","key":"e_1_2_9_77_1","DOI":"10.1159\/000491956"},{"doi-asserted-by":"publisher","key":"e_1_2_9_78_1","DOI":"10.1038\/ncomms9355"},{"doi-asserted-by":"publisher","key":"e_1_2_9_79_1","DOI":"10.1093\/hmg\/ddx045"},{"doi-asserted-by":"publisher","key":"e_1_2_9_80_1","DOI":"10.1097\/BRS.0000000000001394"},{"doi-asserted-by":"publisher","key":"e_1_2_9_81_1","DOI":"10.1038\/s41418-018-0240-2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_82_1","DOI":"10.1002\/stem.1989"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.31119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T17:26:15Z","timestamp":1697736375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.31119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":81,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jcp.31119"],"URL":"https:\/\/doi.org\/10.1002\/jcp.31119","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"type":"print","value":"0021-9541"},{"type":"electronic","value":"1097-4652"}],"subject":[],"published":{"date-parts":[[2023,9,8]]},"assertion":[{"value":"2023-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}