{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:58:17Z","timestamp":1788501497763,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Whether respiratory syncytial virus (RSV) infection in early life may induce orosomucoid 1\u2010like protein 3 (ORMDL3) and lead to NOD\u2010like receptor protein 3 (NLRP3) inflammasome overexpression in asthma, which could be alleviated by the inhibition of HAT p300. First, we explored the relationship between RSV, ORMDL3, and recurrent wheezing in the future through clinical data of infants with RSV\u2010induced bronchiolitis. Then, we used bronchial epithelium transformed with Ad12\u2010SV40 2B (BEAS\u20102B) and an asthmatic mouse model of repeated RSV infection and OVA sensitization and challenge (rRSV + OVA) in early life to assess the effects of ORMDL3 on NLRP3 inflammasome and that of histone acetylation on ORMDL3 regulation. ORMDL3 overexpression is the independent risk factor of recurrent wheezing in RSV\u2010bronchiolitis follow\u2010up. In BEAS\u20102B, ORMDL3\u2010induced NLRP3 inflammasome expression. BEAS\u20102B infected by RSV resulted in overexpression of ORMDL3 and NLRP3 inflammasome and histone hyperacetylation, while ORMDL3\u2010small interfering RNA and C646 interfered could decrease NLRP3 inflammasome. ORMDL3 overexpression in mouse lung increased NLRP3 inflammasome. The expression of ORMDL3 and NLRP3 inflammasome significantly increased, with histone hyperacetylation in the lung in rRSV\u2009+\u2009OVA mice. p300 and acetylH3 bound to ORMDL3 promoter. In C646\u2009+\u2009rRSV\u2009+\u2009OVA mice, C646 alleviated lung inflammation and overexpression of ORMDL3 and NLRP3 inflammasome. RSV activated ORMDL3 overexpression through histone hyperacetylation and induced NLRP3 inflammasome expression.<\/jats:p>","DOI":"10.1002\/jcp.31141","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:05:23Z","timestamp":1698235523000},"page":"2904-2923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Histone acetylation regulates ORMDL3 expression\u2010mediated NLRP3 inflammasome overexpression during RSV\u2010allergic exacerbation mice"],"prefix":"10.1002","volume":"238","author":[{"given":"Qi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Xi'an Children's Hospital Xi'an 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