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Proper exercise improves bone density without the side effects of long\u2010term medications, but the mechanism is unclear. Our study explored the role of Antxr1\/LncRNA H19\/Wnt\/\u03b2\u2010catenin axis in the process of exercise\u2010mediated alleviation of bone loss. Here we discovered that moderate\u2010intensity treadmill exercise alleviates bone loss caused by ovariectomy and ameliorates bone strength accompanied by an increased lncRNA H19 expression. Concomitantly, Antxr1, a mechanosensitive protein was found downregulated by exercise but upregulated by ovariectomy. Interestingly, knockdown expression of Antxr1 increased lncRNA H19 expression and Wnt\/\u03b2\u2010catenin signaling pathway in bone marrow mesenchymal stem cells,\u00a0whereas overexpression of Antxr1 decreased lncRNA H19 expression and Wnt\/\u03b2\u2010catenin signaling pathway. Hence, our study demonstrates the regulation of Antxr1\/LncRNA H19\/Wnt\/\u03b2\u2010catenin axis in the process of mechanical strain\u2010induced osteogenic differentiation, which provides further mechanistic insight into the role of mechanical regulation in bone metabolism.<\/jats:p>","DOI":"10.1002\/jcp.31214","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T08:08:55Z","timestamp":1707984535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mechanical strain regulates osteogenesis via Antxr1\/LncRNA H19\/Wnt\/\u03b2\u2010catenin axis"],"prefix":"10.1002","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-9758","authenticated-orcid":false,"given":"Lifei","family":"Liu","sequence":"first","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport Shanghai China"},{"name":"Department of Rehabilitation The People's Hospital of Liaoning Province Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport Shanghai China"},{"name":"Department of Biomedical Engineering Southern University of Science and Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport Shanghai China"},{"name":"College of Physical Education Qingdao University of Science and Technology Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport Shanghai China"},{"name":"College of Physical Education Yanshan University Qinhuangdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Sports Science Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Bennett","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2021-8309","authenticated-orcid":false,"given":"Jiake","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Western Australia Perth Western Australia Australia"},{"name":"Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6036-8067","authenticated-orcid":false,"given":"Jun","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249759"},{"key":"e_1_2_9_3_1","first-page":"162","article-title":"Effect of sclerostin on the functions and related mechanisms of cementoblasts under mechanical stress","volume":"37","author":"Bai S. 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