{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:59:08Z","timestamp":1788994748681,"version":"build-2803163510"},"reference-count":139,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The development of psoriasis is mainly driven by the dysregulation of T cells within the skin, marking a primary involvement of these cells in the pathogenesis. Although B cells are integral components of the immune system, their role in the initiation and progression of psoriasis is not as pivotal as that of T cells. The paradox of B cell suggests that, while it is crucial for adaptive immunity, B cells may contribute to the exacerbation of psoriasis. Numerous ideas proposed that there are potential relationships between psoriasis and B cells especially within germinal centers (GCs). Recent research projected that B cells might be triggered by autoantigens which then induced molecular mimicry to alter B cells activity within GC and generate autoantibodies and pro\u2010inflammatory cytokines, form ectopic GC, and dysregulate the proliferation of keratinocytes. Hence, in this review, we gathered potential evidence indicating the participation of B cells in psoriasis within the context of GC, aiming to enhance our comprehension and advance treatment strategies for psoriasis thus inviting many new researchers to investigate this issue.<\/jats:p>","DOI":"10.1002\/jcp.31266","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T08:24:09Z","timestamp":1712305449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The immunological understanding on germinal center B cells in psoriasis"],"prefix":"10.1002","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-588X","authenticated-orcid":false,"given":"Aina Akmal Mohd","family":"Noor","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdah Karimah Che Md","family":"Nor","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norhanani Mohd","family":"Redzwan","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Basic immunology e\u2010Book: Functions and disorders of the immune system (Sixth Edition)","author":"Abbas A. 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