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Despite the accessibility of the primary percutaneous coronary intervention and medications that alleviate ventricular remodeling with functional improvement, there is an urgent need for clinicians and basic scientists to further reveal the mechanisms behind post\u2010MI HF as well as investigate earlier and more efficient treatment after MI. Growing numbers of studies have highlighted the crucial role of macrophages in cardiac repair and remodeling following MI, and timely intervention targeting the immune response via macrophages may represent a promising therapeutic avenue. Recently, technology such as single\u2010cell sequencing has provided us with an updated and in\u2010depth understanding of the role of macrophages in MI. Meanwhile, the development of biomaterials has made it possible for macrophage\u2010targeted therapy. Thus, an overall and thorough understanding of the role of macrophages in post\u2010MI HF and the current development status of macrophage\u2010based therapy will assist in the further study and development of macrophage\u2010targeted treatment for post\u2010infarction cardiac remodeling. 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