{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:35:30Z","timestamp":1791992130216,"version":"4.4.0"},"reference-count":215,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epithelial ovarian cancer (EOC) has the highest mortality rate among malignant tumors of the female reproductive system and the lowest survival rate. This poor prognosis is due to the aggressive nature of EOC, its late\u2010stage diagnosis, and the tumor's ability to adapt to stressors through metabolic reprogramming. EOC cells sustain their rapid proliferation by altering the uptake, utilization, and regulation of carbohydrates, lipids, and amino acids. These metabolic changes support tumor growth and contribute to metastasis, chemotherapy resistance, and immune evasion. Targeting these metabolic vulnerabilities has shown promise in preclinical studies, with some therapies advancing to clinical trials. However, challenges remain due to tumor heterogeneity, adaptive resistance mechanisms, and the influence of the tumor microenvironment. This review provides a comprehensive summary of metabolic targets for EOC treatment and offers an overview of the current landscape of clinical trials focusing on ovarian cancer metabolism. Future efforts should prioritize combination therapies that integrate metabolic inhibitors with immunotherapies or chemotherapy. Advances in precision medicine and multi\u2010omics approaches will be crucial for identifying patient\u2010specific metabolic dependencies and improving outcomes. By addressing these challenges, metabolism\u2010based therapies can significantly transform the treatment of this devastating disease.<\/jats:p>","DOI":"10.1002\/jcp.31495","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T01:55:28Z","timestamp":1734314128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring Metabolic Approaches for Epithelial Ovarian Cancer Therapy"],"prefix":"10.1002","volume":"240","author":[{"given":"Sangeeta","family":"Kumari","sequence":"first","affiliation":[{"name":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Jamil","sequence":"additional","affiliation":[{"name":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyana","family":"Tabatabaei","sequence":"additional","affiliation":[{"name":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania USA"},{"name":"Department of Biology, College of Science and Technology Temple University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Karakashev","sequence":"additional","affiliation":[{"name":"Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania USA"},{"name":"Nuclear Dynamics and Cancer Program Fox Chase Cancer Center Philadelphia Pennsylvania USA"},{"name":"Cancer Epigenetics Institute Fox Chase Cancer Center Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2005805"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2019.12.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31758"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-1702"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100842"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.0933"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18044002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0511-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24918"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.56.070187.000245"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-020-00920-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00785"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19435"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133247"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.10.015"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0391-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/205357"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112495109"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00342"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040535"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1943253"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104656"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11192-8"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.905814"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1945"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2013.849722"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2017.178"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310668"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.04.029"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.03.034"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040828"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-020-00718-4"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0968-0004(98)01344-9"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600200"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25202"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05595-4"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00532-x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20057"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02523"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9667"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.022"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.09.018"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140100"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-021-00767-3"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.11.1933"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24055041"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.541300"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114092"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-1064"},{"issue":"5","key":"e_1_2_10_55_1","first-page":"1169","article-title":"Antidiabetic Drug Metformin Mitigates Ovarian Cancer SKOV3 Cell Growth by Triggering G2\/M Cell Cycle Arrest and Inhibition of m\u2010TOR\/PI3K\/Akt Signaling Pathway","volume":"21","author":"Fu Y. L.","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1958174"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867326666181213092652"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00365"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030937"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.015"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106020"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1322-x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/343425a0"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.02.016"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.09.001"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-S4-S2"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520622666220513163341"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4984-3"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0329"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-1624"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112352"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/21541248.2016.1232583"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13525"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2334"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.738177"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-18-0572"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69600"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.015"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104628"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04263-8"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2641"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9317"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059344"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205251"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.120"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)62146-7"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.593017"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29137-3"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00971-9"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01493-z"},{"issue":"12","key":"e_1_2_10_92_1","first-page":"2478","article-title":"Atorvastatin Exhibits Anti\u2010Tumorigenic and Anti\u2010Metastatic Effects in Ovarian Cancer","volume":"7","author":"Jones H. M.","year":"2017","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10280"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1405"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00849.x"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03477-6"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00771.x"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0054-z"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.08.009"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2017.1333552"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00962-1"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2166-5"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.07.031"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3790"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101753"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1505"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S270688"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2070-4"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0375-3"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0830-7"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2295-8"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.05.014"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.86279"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127905"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00909-0"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15900"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11010033"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26814"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14014"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524011313040005"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209603"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0635-5"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2222"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403390101"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.08.015"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1602S"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.247"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.340083"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24546"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2492"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010755"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557511313080007"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.10.044"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000001215"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14410"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2020.56.9.3168443"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.06.005"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.06.014"},{"issue":"6","key":"e_1_2_10_139_1","first-page":"1189","article-title":"Inhibition of Fatty Acid Synthesis Delays Disease Progression in a Xenograft Model of Ovarian Cancer","volume":"56","author":"Pizer E. S.","year":"1996","journal-title":"Cancer Research"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.04.020"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2010.05.014"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-11-0126"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmx106"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08644.x"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3891"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4464"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.11.019"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.03.003"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28185"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.11.022"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-3971"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.05.091"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.728759"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.09.013"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12020271"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-013-0250-9"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2018.06.005"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0369"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188457"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-08-0196"},{"issue":"2","key":"e_1_2_10_162_1","first-page":"361","article-title":"Expression of Glucose Transporters in Epithelial Ovarian Carcinoma: Correlation With Clinical Characteristics and Tumor Angiogenesis","volume":"18","author":"Tsukioka M.","year":"2007","journal-title":"Oncology Reports"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3144"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29261"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-138"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21545"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11121749"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S212465"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-023-01196-0"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106490"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194795"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.1638"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.589508"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M016089"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.642229"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.603837"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.015"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0960862"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.05.003"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-00160-x"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-4047"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6636791"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.769196"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.070"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4521-4"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188394"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.70194"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01510"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.08.018"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2016.1223296"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091055"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49649-1"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1018642"},{"key":"e_1_2_10_195_1","first-page":"3001","volume-title":"First\u2010in\u2010Human Biomarker\u2010Driven Phase I Trial of the Potent and Selective Glutaminase\u20101 (GLS1) Inhibitor IACS\u20106274 (IPN60090) in Patients (pts) With Molecularly Selected Advanced Solid Tumors","author":"Yap T. A.","year":"2021"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010140"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.08.027"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5864826"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.864244"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02645-2"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.01.019"},{"issue":"10","key":"e_1_2_10_202_1","first-page":"4265","article-title":"Glutaminase Inhibitor Compound 968 Inhibits Cell Proliferation and Sensitizes Paclitaxel in Ovarian Cancer","volume":"8","author":"Yuan L.","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00500"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-4112"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696151"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00720-4"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13116-2"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101023"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2016.08.40"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2203480119"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00637"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03336-6"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370218760283"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01398"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00060"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11355"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.31495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T07:31:13Z","timestamp":1748503873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.31495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,15]]},"references-count":215,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/jcp.31495"],"URL":"https:\/\/doi.org\/10.1002\/jcp.31495","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,15]]},"assertion":[{"value":"2024-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31495"}}