{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:38:33Z","timestamp":1761673113105,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer\u2010related mortalities worldwide. Understanding the mechanisms driving tumor growth and metastasis in gastric cancer is essential for the development of effective therapeutic strategies. In this regard, it is well\u2010established that CD200, a glycoprotein that binds to the CD200 receptor, has notable immunosuppressive effects. The extracellular domain of CD200 is secreted into the tumor microenvironment (TME), wherein it promotes cancer progression. However, although CD200 is highly expressed in several types of cancers, the details of its intracellular roles in tumor progression remain poorly understood. In this study, we investigated the biological function and mechanism of action of CD200 in gastric cancer. Public datasets from GSE and TCGA revealed that CD200 is overexpressed in gastric cancer and that its expression is correlated with cancer stage and metastasis. Functionally, we found that CD200 enhances cell proliferation, migration, and invasion, and also promotes the expression of epithelial\u2010mesenchymal transition (EMT)\u2010related genes. Mechanistically, CD200 was demonstrated activate the WNT\/\u03b2\u2010catenin signaling pathway by inducing \u03b2\u2010catenin activation. Notably, we established that the cytoplasmic domain of CD200 binds directly to \u03b2\u2010catenin, thereby facilitating its nuclear translocation. The CD200\/\u03b2\u2010catenin\/TCF4 complex subsequently promotes the transcription of \u03b2\u2010catenin target and EMT\u2010related genes. Collectively, our findings in this study revealed that the cytoplasmic domain of CD200 interacts with \u03b2\u2010catenin, thereby promoting the transcriptional activation of \u03b2\u2010catenin target genes and inducing tumor growth and metastasis in gastric cancer. These findings accordingly indicate that CD200 may serve as a potential therapeutic target for the treatment of gastric cancer.<\/jats:p>","DOI":"10.1002\/jcp.70101","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T09:45:57Z","timestamp":1759830357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD200 Promotes Gastric Cancer Progression and Metastasis by Inducing the \u03b2\u2010catenin Signaling Pathway"],"prefix":"10.1002","volume":"240","author":[{"given":"Hana","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Integrative Biological Sciences &amp; BK 21 FOUR Educational Research Group for Age\u2010associated Disorder Control Technology Chosun University Gwangju Republic of Korea"},{"name":"Institute of Well\u2010Aging Medicare &amp; Chosun University G\u2010LAMP Project group Chosun University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang\u2010Mi","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Integrative Biological Sciences &amp; BK 21 FOUR Educational Research Group for Age\u2010associated Disorder Control Technology Chosun University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Phil","family":"Shin","sequence":"additional","affiliation":[{"name":"Bio R&amp;D center Samsung biologics Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Well\u2010Aging Medicare &amp; Chosun University G\u2010LAMP Project group Chosun University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Integrative Biological Sciences &amp; BK 21 FOUR Educational Research Group for Age\u2010associated Disorder Control Technology Chosun University Gwangju Republic of Korea"},{"name":"Institute of Well\u2010Aging Medicare &amp; Chosun University G\u2010LAMP Project group Chosun University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon\u2010Gu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Integrative Biological Sciences &amp; 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