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In this population, bone health is a critical concern due to both therapy\u2010induced bone loss and a high propensity for skeletal metastasis. Antiresorptive agents are widely used; however, their known adverse effects and limited capacity to rapidly reduce fracture risk in high\u2010risk individuals have led to growing support for the early use of osteoanabolic therapies. Among these, intermittent administration of parathyroid hormone [PTH (1\u201334)] has demonstrated clinical efficacy in reducing fracture risk by activating the PTH 1 receptor in osteoblasts. However, its safety and mechanistic relevance in the context of breast cancer remain poorly understood. This review outlines the osteoblast\u2010specific signaling pathways of PTH (1\u201334) and includes our recent research that identified p21\u2010activated kinase 4 as a downstream effector linking canonical cyclic adenosine monophosphate\u2010protein kinase A signaling to Wnt\/\u03b2\u2010catenin activation. Additionally, it explores the potential implications of PTH (1\u201334) in the context of breast cancer\u2010related bone metastasis.<\/jats:p>","DOI":"10.1002\/jcp.70115","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T18:23:40Z","timestamp":1764354220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parathyroid Hormone (1\u201334) Signaling for Bone Health in Breast Cancer Survivorship and Metastasis"],"prefix":"10.1002","volume":"240","author":[{"given":"Shinyoung","family":"Oh","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Jeonbuk National University Medical School Jeonju Republic of Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital Jeonju Republic of Korea"},{"name":"Department of 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