{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T08:40:25Z","timestamp":1764146425886,"version":"3.46.0"},"reference-count":5,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>In their recent study, Zeng et al. (2025) employed single\u2010cell RNA sequencing to delineate the landscape of spinal cord injury (SCI), highlighting a previously underappreciated communicative role for endothelial tip cells in engaging astrocytes and macrophages. While their work provides a valuable resource and generates compelling hypotheses, it also opens several critical avenues that demand immediate scrutiny. This Letter offers a prospective outlook and a critical examination of their findings. We argue that the computationally predicted paracrine networks, such as the Angptl4\u2010Sdc4 axis identified by the authors, require rigorous in vivo functional validation to establish causality. Furthermore, the current snapshot data lack the temporal and spatial resolution necessary to decipher the dynamics of these interactions. Most importantly, we explore the therapeutic dilemma of targeting tip cells\u2014a strategy that must delicately balance their detrimental signaling roles against their indispensable function in revascularization. Addressing these challenges is paramount to transforming these descriptive insights into mechanistic understanding and viable therapeutic strategies for SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Pre\u2010Registered Clinical Trial Number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.70117","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T10:27:42Z","timestamp":1764066462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Single\u2010Cell Atlas to Functional Validation: Critical Next Steps for Understanding Tip Cell\u2010Mediated Communication in the Injured Spinal Cord"],"prefix":"10.1002","volume":"240","author":[{"given":"DuJiang","family":"Yang","sequence":"first","affiliation":[{"name":"The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou Sichuan Province P.R. China"},{"name":"Center for Orthopedic Diseases Research, The Affiliated Traditional Chinese Medicine Hospital Southwest Medical University Luzhou Sichuan Province P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiexiang","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou Sichuan Province P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-0572","authenticated-orcid":false,"given":"GuoYou","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou Sichuan Province P.R. China"},{"name":"Center for Orthopedic Diseases Research, The Affiliated Traditional Chinese Medicine Hospital Southwest Medical University Luzhou Sichuan Province P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_1_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202503479"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.03.007"},{"key":"e_1_2_1_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2024.07.001"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401234"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.70088"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T08:35:17Z","timestamp":1764146117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jcp.70117"],"URL":"https:\/\/doi.org\/10.1002\/jcp.70117","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"type":"print","value":"0021-9541"},{"type":"electronic","value":"1097-4652"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70117"}}