{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:39:32Z","timestamp":1790746772531,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08344"],"award-info":[{"award-number":["18K08344"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cluster of differentiation 14\n                    <jats:sup>+<\/jats:sup>\n                    monocytes produced spindle\u2010shaped fibrocytes, similar to fibroblasts. Recent studies have reported that fibrocytes are crucial for the development and progression of primary myelofibrosis (MF); however, their functional role remains unclear. We compared monocytes and fibrocytes using RNA sequencing for gene expression profiles. We focused on chitinase 3\u2013like\u20101 (CHI3L1), which causes inflammation, organ fibrosis, and extracellular tissue remodeling. We found higher CHI3L1 levels in patients with myeloproliferative neoplasm with MF than in those without MF. Further, serum CHI3L1 levels were significantly associated with the presence of MF and splenomegaly in patients with lymphoid tumors. Romiplostim\u2010induced MF in a mouse model demonstrated extensive bone marrow (BM)\n                    <jats:italic>CHI3L1<\/jats:italic>\n                    mRNA expression, which was reversed by clodronate treatment. Two MF induction experiments on\n                    <jats:italic>CHI3L1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice, based on romiplostim or Janus kinase 2 mutations, revealed fewer reticular fibers in silver\u2010stained BM slices than in wild\u2010type mice. A culture assay revealed that high CHI3L1 concentrations promoted extracellular matrix production by fibroblast cell lines, and that a CHI3L1\u2010neutralizing antibody abrogated this effect. These results indicate the importance of CHI3L1 in the association between fibrocytes and fibroblasts in MF and could be a focus for future treatment.\n                  <\/jats:p>","DOI":"10.1002\/jcp.70166","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:35:13Z","timestamp":1775468113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Chitinase 3\u2013like\u20101 in Myelofibrosis via Fibroblast\u2010Produced Extracellular Matrix Enhancement"],"prefix":"10.1002","volume":"241","author":[{"given":"Shoichiro","family":"Kato","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikuni","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-0862","authenticated-orcid":false,"given":"Takaaki","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College Tokorozawa Saitama Japan"},{"name":"Division of Palliative Care National Defense Medical College Hospital Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5013-3088","authenticated-orcid":false,"given":"Hiraku","family":"Ogata","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College Tokorozawa Saitama Japan"},{"name":"Division of Biochemistry, Department of Biomedical Sciences Nihon University School of Medicine Oyaguchi Kami\u2010cho Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Tachi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Osawa","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12332"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.075846"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.mct-10-0868"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-96"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13396"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v51.2.189.bloodjournal512189"},{"key":"e_1_2_12_9_1","first-page":"172","article-title":"Studies on Serum YKL\u201040 as a Biomarker in Diseases With Inflammation, Tissue Remodelling, Fibroses and Cancer","volume":"53","author":"Johansen J. 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