{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:42:10Z","timestamp":1789065730390,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The circadian clock orchestrates adipocyte development and lipid remodeling, with its disruption leading to the development of obesity and insulin resistance. Here we demonstrate that the flavonoid compound naringenin displays clock modulatory activity that suppresses adipocyte lipid storage while promoting browning. In adipogenic progenitors, naringenin activates ROR\u03b1 with induction of clock gene expression to promote circadian clock oscillation with protective effect against cytokine\u2010induced dampening. The clock\u2010enhancing properties of naringenin suppressed lipogenesis in mature adipocytes together with induction of browning characteristics. The inhibitory effect of naringenin on lipogenesis was dependent on clock modulation as it was abolished in ROR\u03b1\u2010deficient adipocytes. We further show that naringenin administration in vivo up\u2010regulated ROR\u03b1 expression with clock gene induction together with browning of subcutaneous beige fat depot, resulting reduced fat mass and body weight. Naringenin treatment in vivo also lowered plasma glucose and free fatty acid levels, with markedly enhanced insulin signaling in adipose depots and skeletal muscle. Collectively, our findings uncover a new clock\u2010activating mechanism of action in mediating the metabolic benefits of naringenin, suggesting its potential as a natural supplement for anti\u2010obesity and metabolic disease interventions.<\/jats:p>","DOI":"10.1002\/jcp.70175","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:20:59Z","timestamp":1776320459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clock Modulation by Naringenin Suppresses Lipogenesis and Promotes Adipose Tissue Browning"],"prefix":"10.1002","volume":"241","author":[{"given":"Xuekai","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Diabetes Complications and Metabolism Beckman Research Institute of City of Hope Duarte California 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