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The HSC niche critically regulates tropism and proliferation via factors secreted by the microenvironment interaction. Here, we hypothesized that HSCs display tropism toward the aggressive cancer stem cell (CSC) niches of triple\u2010negative breast cancer (TNBC) and MCF\u20107 cells breast cancer, which exhibit high relapse rates and are potential targets for cell therapy. Our results demonstrate HSC\u2010specific tropism toward breast CSCs, leading to interactions that trigger HSC differentiation into CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    subpopulations within the cancer microenvironment. Proteomics of migrated HSCs toward TNBC\u2010CSCs\/MCF\u20107 cells revealed significant upregulation of IL\u20107, Notch, and other proteins involved in T cell activation and migration pathways. Metabolomics of HSC\u2010conditioned medium (HSC\u2010CM)\u2010treated CSCs\/MCF\u20107 cells further demonstrated that HSC\u2010CM arrests TNBC\u2010CSC growth and cell cycle progression by altering the mitochondrial bioenergetics. This study highlights the potential of leveraging both HSCs and HSC\u2010derived factors for personalized therapies targeting CSCs in TNBC.\n                  <\/jats:p>","DOI":"10.1002\/jcp.70179","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:34:31Z","timestamp":1777959271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hematopoietic Stem Cell Tropism Mediated Targeting of Breast Cancer Stem Cells via Alteration of Tumor Immune\u2010Microenvironment"],"prefix":"10.1002","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-0354","authenticated-orcid":false,"given":"Sumit","family":"Mallick","sequence":"first","affiliation":[{"name":"Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre Yenepoya (Deemed to be University) Mangalore Karnataka India"},{"name":"Current affiliation: Division of Molecular Genetics and Cancer Nitte University 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