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This study investigated mitochondria\u2010related genes in presbycusis, a condition with multifactorial and incompletely understood mechanisms, by combining Mendelian randomization analysis and functional validation. Genetically predicted higher\n                    <jats:italic>ABHD10<\/jats:italic>\n                    expression was identified as a protective factor against presbycusis and was regulated by methylation sites such as cg15684481, whereas methylation at other sites inhibited\n                    <jats:italic>ABHD10<\/jats:italic>\n                    expression and alleviated the condition. In contrast,\n                    <jats:italic>ABHD10<\/jats:italic>\n                    was upregulated in\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose\u2010induced HEI\u2010OC1 cells and aged mouse cochlear hair cells, where it promoted senescence. Silencing\n                    <jats:italic>ABHD10<\/jats:italic>\n                    in senescent cells reduced P21 and P16 protein levels, decreased reactive oxygen species levels, improved mitochondrial membrane potential, and lowered lipid droplet formation along with triglycerides and fatty acids. Co\u2010immunoprecipitation experiments showed that\n                    <jats:italic>ABHD10<\/jats:italic>\n                    interacts with\n                    <jats:italic>KCMF1<\/jats:italic>\n                    , indicating that the complex may regulate cellular metabolism and stress responses through signaling pathways. This was supported by GO and KEGG analyses linking\n                    <jats:italic>ABHD10<\/jats:italic>\n                    to aging\u2010related processes such as energy metabolism and oxidative stress. Overall,\n                    <jats:italic>ABHD10<\/jats:italic>\n                    functions as a context\u2010dependent mitochondrial regulator, with the\n                    <jats:italic>ABHD10\u2010KCMF1<\/jats:italic>\n                    axis integrating mitochondrial quality control, lipid homeostasis, and redox balance, thereby offering a potential druggable target for presbycusis.\n                  <\/jats:p>","DOI":"10.1002\/jcp.70193","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:32:47Z","timestamp":1779967967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <i>ABHD10\u2010KCMF1<\/i>\n                    Complex Mitigates Cochlear Aging by Regulating Mitochondrial Lipid Metabolism"],"prefix":"10.1002","volume":"241","author":[{"given":"Lu","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery the Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-7745","authenticated-orcid":false,"given":"Xingwei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery the Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery the Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery the Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery the Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanrong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery the Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery the Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi 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