{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:22:46Z","timestamp":1779927766486,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Palmitoyl ethanol amide (PEA) is an endogenous substance that plays a role in neuropathic pain. In this article, we evaluated both the safety and the efficacy of ultramicronized PEA (um\u2010PEA) in the treatment of low back pain related to nonsurgical lumbar radiculopathy. In this prospective single\u2010blind study, patients with low back pain related to nonsurgical lumbar radiculopathy received the fixed combination acetaminophen\/codeine (500\u00a0mg\u00a0+\u00a030\u00a0mg\/d) for 7\u00a0days, and then it was stopped and changed to um\u2010PEA (1200\u00a0mg\/d) for 30\u00a0days. Patients without an improvement in pain or disability started a second cycle of treatment with um\u2010PEA (600\u00a0mg\/d in tablets) for 30\u00a0days and then acetaminophen\/codeine for 30\u00a0days. A total of 155 patients were included in the analysis. After the first cycle of treatment we recorded an improvement of pain in all patients with mild pain (visual analog scale score from 3\u20104 to 1) and in 75% of the patients with moderate pain (visual analog scale score from 5\u20106 to 2). After the second cycle, we recorded an improvement of pain and disability in all patients with moderate pain (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), but in 26% of patients with severe pain we did not record any improvement in disability (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). In conclusion we evaluated the role of um\u2010PEA in patients with lumbar radiculopathy with a long\u2010term follow\u2010up (24\u00a0months) and put in evidence the effectiveness and the safety of this formulation in patients with mild and moderate pain.<\/jats:p>","DOI":"10.1002\/jcph.1070","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T14:07:03Z","timestamp":1516802823000},"page":"733-739","source":"Crossref","is-referenced-by-count":17,"title":["N\u2010Palmitoyl Ethanol Amide Pharmacological Treatment in Patients With Nonsurgical Lumbar Radiculopathy"],"prefix":"10.1002","volume":"58","author":[{"given":"Domenico","family":"Chirchiglia","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Science School of Medicine, University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Paventi","sequence":"additional","affiliation":[{"name":"Anaesthesia and Resuscitation Operative Unit Santo Spirito Hospital  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Seminara","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Azienda Sanitaria Provinciale  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Cione","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Health and Nutritional Sciences University of Calabria  Rende CS Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[{"name":"Department of Health Science University of Catanzaro, and Clinical Pharmacology and Pharmacovigilance Operative Unit, MaterDomini Hospital Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259085.61898.9e"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000210956.31997.89"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2012.12.001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31825d213d"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318145a3c5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1236-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.07.028"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.06.026"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200727020-00004"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-012-0011-7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.03.015"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-014-1452-0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.057"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.002"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9294"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-011-0672-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091228"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2012.01432.x"},{"issue":"2","key":"e_1_2_5_20_1","first-page":"99","article-title":"Palmitoylethanolamide versus a nonsteroidal anti\u2010inflammatory drug in the treatment of temporomandibular joint inflammatory pain","volume":"26","author":"Marini I","year":"2012","journal-title":"J Orofacial Pain"},{"key":"e_1_2_5_21_1","first-page":"849623","article-title":"Micronized palmitoylethanolamide reduces the symptoms of neuropathic pain in diabetic patients","volume":"2014","author":"Schifilliti C","year":"2014","journal-title":"Pain Res Treat"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152711799219307"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12162"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574886311207040309"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488609789006912"},{"issue":"7","key":"e_1_2_5_26_1","first-page":"601","article-title":"Pharmacokinetic drug\u2010drug interaction and their implication in clinical management","volume":"18","author":"Palleria C","year":"2013","journal-title":"J Res Med Sci"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01577a066"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/28393"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90939-3"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13020"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.14.15917"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.07.021"},{"issue":"20","key":"e_1_2_5_33_1","first-page":"3139","article-title":"Paracetamol\u2010codeine compared to ketorolac for pain control in the emergency department.","volume":"18","author":"Buccelletti F","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"e_1_2_5_34_1","first-page":"11","article-title":"Palmitoylethanolamide, a special food for medical purposes, in the treatment of chronic pain: a pooled data meta\u2010analysis.","volume":"19","author":"Paladini A","year":"2016","journal-title":"Pain Physician"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000623"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcph.1070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.1070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T23:20:35Z","timestamp":1694301635000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.1070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/jcph.1070"],"URL":"https:\/\/doi.org\/10.1002\/jcph.1070","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,24]]}}}