{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:31:25Z","timestamp":1788262285294,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The most commonly used Parkinson's disease (PD) treatment is the replacement of dopamine by its levodopa precursor (<jats:sc>l<\/jats:sc>\u2010dopa). Monoamine oxidase\u2010B (MAO\u2010B) and catechol\u2010o\u2010methyl transferase (COMT) are enzymes involved in the metabolism and regulation of dopamine availability. In our study we investigated the possible relation among selected single\u2010nucleotide polymorphisms (SNPs) in the<jats:italic>MAO\u2010B<\/jats:italic>(rs1799836) and<jats:italic>COMT<\/jats:italic>(rs4680) genes and the therapeutic response to levodopa (<jats:sc>l<\/jats:sc>\u2010dopa). A total of 162 Brazilian patients from the Pro\u2010Parkinson service of Clinics Hospital of Pernambuco diagnosed with sporadic PD and treated with levodopa were enrolled. PD patients were stratified into 2 groups according to the daily levodopa dose.<jats:italic>MAO\u2010B<\/jats:italic>and<jats:italic>COMT<\/jats:italic>SNP genotyping was conducted by polymerase chain reaction\u2013restriction fragment length polymorphism. After multivariate analysis, we observed a significant difference between PD groups for the following variables: sex (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), longer duration of disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), longer levodopa therapy duration (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), younger onset of PD (<jats:italic>P =<\/jats:italic>.01), and use of COMT inhibitor (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). We observed that patients carrying<jats:italic>MAO\u2010B<\/jats:italic>(rs1799836) A and AA genotypes and COMT (rs4680) LL genotype suffered more frequently from levodopa\u2010induced\u2010dyskinesia. In addition, we found an increased risk of 2.84\u2010fold for male individuals carrying the<jats:italic>MAO\u2010B<\/jats:italic>G allele to be treated with higher doses of levodopa (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). We concluded that before beginning PD pharmacological treatment, it is important to consider the genetic variants of the<jats:italic>MAO\u2010B<\/jats:italic>and<jats:italic>COMT<\/jats:italic>genes and the sex, reinforcing the evidence that sexual dimorphism in the genes related to dopamine metabolism might affect PD treatment.<\/jats:p>","DOI":"10.1002\/jcph.1096","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T14:08:36Z","timestamp":1522073316000},"page":"920-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["<i>MAO\u2010B<\/i>and<i>COMT<\/i>Genetic Variations Associated With Levodopa Treatment Response in Patients With Parkinson's Disease"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-5777","authenticated-orcid":false,"given":"Tiago Furtado","family":"Sampaio","sequence":"first","affiliation":[{"name":"Postgraduate Program of Biology Applied to Health Federal University of Pernambuco (UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinaldo Ubirajara Damasceno","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Applied Cellular and Molecular Biology University of Pernambuco (UPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gessica Dayane Cordeiro","family":"de Lima","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Applied Cellular and Molecular Biology University of Pernambuco (UPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rute Salgues Gueiros","family":"dos Anjos","sequence":"additional","affiliation":[{"name":"Department of Genetics Federal University of Pernambuco (UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo Celerino","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Biology Applied to Health Federal University of Pernambuco (UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amdore Guescel C.","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Medicine Federal University of Pernambuco (UFPE) Recife Brazil"},{"name":"Pro\u2010Parkinson Program of Clinical Hospital of Federal University of Pernambuco e Recife (HC\/UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja Maria Jorge","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Medicine Federal University of Pernambuco (UFPE) Recife Brazil"},{"name":"Pro\u2010Parkinson Program of Clinical Hospital of Federal University of Pernambuco e Recife (HC\/UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[{"name":"Department of Genetics Federal University of Pernambuco (UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-9849","authenticated-orcid":false,"given":"Paulo Roberto Eleut\u00e9rio","family":"de Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Biology Applied to Health Federal University of Pernambuco (UFPE) Recife Brazil"},{"name":"Postgraduate Program of Applied Cellular and Molecular Biology University of Pernambuco (UPE) Recife Brazil"},{"name":"Department of Biology Federal Rural University of Pernambuco (UFRPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9581-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000247740.47667.03"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"Clinical approach to Parkinson's disease: features, diagnosis, and principles of management","volume":"2","author":"Bhatia KP","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a1d44c"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"442","article-title":"Pharmacological treatment of Parkinson disease","volume":"311","author":"Pahwa R","year":"2014","journal-title":"J Neurol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033447"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2723"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10268"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328306c2f2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.10.006"},{"issue":"1","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000351097","article-title":"Influence of single nucleotide polymorphisms in COMT, MAO\u2010A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease","volume":"13","author":"Cheshire P","year":"2013","journal-title":"Neurodegener Dis"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.02.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.55782\/ane-2012-1900","article-title":"The catechol\u2010O\u2010methyltransferase and monoamine oxidase B polymorphisms and levodopa therapy in the Iranian patients with sporadic Parkinson's disease","volume":"72","author":"Torkaman\u2010boutorabi A","year":"2012","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2014.12"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.533"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20410"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.3.375"},{"key":"e_1_2_9_21_1","first-page":"364","article-title":"Bio estat 5.0: aplica\u00e7\u00f5es estat\u00edsticas nas \u00e1reas das ci\u00eancias biol\u00f3gicas e m\u00e9dicas","volume":"2007","author":"Ayres M","journal-title":"Bioestat Apl estat\u00edstica nas \u00e1reas das ciencias bio\u2010m\u00e9dicas"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.11.2297"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23805"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074637"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.183"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.035980"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:30:1:077"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.020982"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2016.1182021"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0652-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020070075"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10624"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00315.x"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcph.1096","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.1096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T09:44:44Z","timestamp":1719913484000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.1096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/jcph.1096"],"URL":"https:\/\/doi.org\/10.1002\/jcph.1096","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]},"assertion":[{"value":"2017-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}