{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:41:56Z","timestamp":1775886116196,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured ceftriaxone pharmacokinetics in patients\u2019 plasma and cerebrospinal fluid (CSF) and assessed the influence of biometric, demographic, genetic (<jats:italic>ABCB1<\/jats:italic>,<jats:italic>ABCC2, ABCB11, ABCG2<\/jats:italic>, and<jats:italic>SLCO1A2<\/jats:italic>polymorphisms) and pathological features. Adult patients with signs and symptoms of central nervous system infections, receiving intravenous ceftriaxone, were enrolled. Ceftriaxone plasma and CSF concentrations were measured by high\u2010precision liquid chromatographic methods; allelic discrimination was performed by real\u2010time polymerase chain reaction. Forty\u2010three patients were included: median ceftriaxone maximal concentration was 15,713 ng\/mL in plasma and 3512 ng\/mL in CSF with a CSF\u2010to\u2010plasma ratio of 0.3.<jats:italic>ABCC2 1249 rs2273697<\/jats:italic>(<jats:italic>P<\/jats:italic>= .027) and<jats:italic>ABCG2 1194+928 rs13120400<\/jats:italic>(<jats:italic>P<\/jats:italic>= .015) variants were significantly associated with CSF concentrations and CSF\u2010to\u2010plasma ratios. At linear regression analysis, CSF\u2010to\u2010serum albumin ratio was an independent predictor of ceftriaxone CSF concentrations (<jats:italic>P =<\/jats:italic>.001; also in those with intact blood\u2010brain barrier:<jats:italic>P<\/jats:italic>= .031) and CSF\u2010to\u2010plasma ratio (<jats:italic>P<\/jats:italic>= .001; also in those with blood\u2010brain barrier impairment:<jats:italic>P<\/jats:italic>= .040). We here report the role of transporters\u2019 genetic variants as well as of blood\u2010brain barrier permeability in predicting ceftriaxone exposure in the central nervous system.<\/jats:p>","DOI":"10.1002\/jcph.1266","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T15:45:45Z","timestamp":1528299945000},"page":"1550-1556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of<i>ABCC2<\/i>and<i>ABCG2<\/i>Gene Polymorphisms and CSF\u2010to\u2010Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations"],"prefix":"10.1002","volume":"58","author":[{"given":"Sarah","family":"Allegra","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Unit of Infectious Diseases, University of Turin Amedeo di Savoia Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara 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