{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:51:30Z","timestamp":1784029890722,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Korean Ministry of Food and Drug Safety","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Food and Drug Safety of South Korea"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate the safety and tolerability of intravenous (IV) levetiracetam (LEV) as a monotherapy in children aged 1 month\u201016 years and to explore the pharmacokinetics (PK) of IV LEV and the time to seizure after IV then oral administration of LEV in pediatric children with epilepsy. Children diagnosed with acute unprovoked seizures requiring in\u2010hospital IV LEV administration were included. After administration, the clinical seizure outcomes, side effects, and the Korean\u2010Child Behavior Checklist were monitored and the PK and repeated time to seizure were analyzed via modeling using NONMEM software. Overall, 37 children with epilepsy were enrolled and underwent a PK analysis (median age, 4.6\u00a0years; median weight, 18.0\u00a0kg). Nine children (24.3%) had seizure recurrence during the follow\u2010up period (median, 3.8\u00a0months) and 5 children (13.5%) experienced LEV\u2010associated adverse events such as irritability (n\u00a0=\u00a02; 5.4%) and somnolence (n\u00a0=\u00a03; 8.1%). The plasma LEV concentrations after IV LEV were best described by a one\u2010compartment linear PK model. Only body weight was associated with both the clearance and volume of distribution of LEV. The Weibull distribution model described the time to seizure recurrence well; no statistically significant predictor for the time to seizure was identified. Therefore, IV LEV was a well\u2010tolerated and effective alternative in children with acute unprovoked seizures, and models for the PK and time to repeated seizure recurrence after LEV were successfully developed. In particular, the current use of a weight\u2010based IV LEV dosing regimen in pediatric children is practical.<\/jats:p>","DOI":"10.1002\/jcph.1282","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T12:45:08Z","timestamp":1532695508000},"page":"1586-1596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pharmacokinetic and Pharmacodynamic Evaluation of Intravenous Levetiracetam in Children With Epilepsy"],"prefix":"10.1002","volume":"58","author":[{"given":"Min\u2010Jee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010Sun","family":"Yum","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital University of Ulsan College of 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