{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:49:40Z","timestamp":1762098580702,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","award":["Beca Dr. Pedro Zarco"],"award-info":[{"award-number":["Beca Dr. Pedro Zarco"]}],"id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic kidney disease (CKD) is associated with worse clinical outcomes in patients with acute coronary syndrome. However, they are underrepresented in clinical trials. We aimed to investigate differences in prognosis of acute coronary syndrome patients with and without CKD, focusing on the use of novel P2Y<jats:sub>12<\/jats:sub> receptor inhibitors. This multicenter registry involved patients with acute coronary syndrome from 3 tertiary institutions. After excluding anticoagulated patients and patients on antiplatelet monotherapy, 1280 patients remained. During 1 year of follow\u2010up, we recorded all major adverse cardiovascular events (composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal ischemic stroke), bleeds (Bleeding Academic Research Consortium classification) and deaths. Of 1280 patients, 325 (25.4%) had CKD; 55.5% of non\u2010CKD patients and 22.7% of CKD patients were prescribed novel P2Y<jats:sub>12<\/jats:sub> inhibitors. During follow\u2010up, CKD patients under novel P2Y<jats:sub>12<\/jats:sub> inhibitors showed a not statistically significant lower mortality and incidence of thrombotic events than clopidogrel\u2010treated ones. In contrast, non\u2010CKD patients taking novel P2Y<jats:sub>12<\/jats:sub> inhibitors had better outcomes in terms of major adverse cardiovascular events (4.72 vs 9.41; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), all\u2010cause mortality (1.32 vs 4.24; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), and severe bleeding events (Bleeding Academic Research Consortium 3\u20105) (0.94 vs 2.82; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.030), without differences for any bleeding (8.11 vs 8.47; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.849). Bleeding risk was not increased by using third\u2010generation P2Y<jats:sub>12<\/jats:sub> inhibitors in either group of patients. In conclusion, the use of third\u2010generation P2Y<jats:sub>12<\/jats:sub> inhibitors among non\u2010CKD patients was associated with better outcomes. CKD patients receiving third\u2010generation P2Y<jats:sub>12<\/jats:sub> inhibitors treatment showed no statistically significant lower mortality and thrombotic events. Bleeding risk was not increased with the use of third\u2010generation P2Y<jats:sub>12<\/jats:sub> inhibitors in either group of patients.<\/jats:p>","DOI":"10.1002\/jcph.1318","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T14:23:27Z","timestamp":1536762207000},"page":"295-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Kidney Disease and Third\u2010Generation P2Y<sub>12<\/sub> Inhibitors Use in Patients With Acute Coronary Syndrome: Impact on the Prognosis at 1 Year"],"prefix":"10.1002","volume":"59","author":[{"given":"Antonio","family":"Tello\u2010Montoliu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca) CIBERCV  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan 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