{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T01:10:03Z","timestamp":1720833003954},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to predict the area under the curve (AUC) of the initial busulfan dose using a test dose with the sparse sampling scheme in adult patients who underwent hematopoietic cell transplant. A test dose of 0.8 mg\/kg busulfan was used 2 days before twice\u2010daily intravenous busulfan\u2010based conditioning regimens were administered. The AUC and the clearance (CL) were calculated for both the test dose and the first dose (AUC<jats:sub>T<\/jats:sub>, CL<jats:sub>T<\/jats:sub>, AUC<jats:sub>1,<\/jats:sub>and CL<jats:sub>1<\/jats:sub>) by noncompartmental analysis. The sparse sampling schemes of the test dose were developed by Bayesian method based on the population pharmacokinetic model. The optimal sparse sampling schemes were determined by evaluating the mean prediction error, the root mean square error, the absolute mean prediction error, and Bland\u2010Altman plot. The mean AUC<jats:sub>1<\/jats:sub>was 7.20 \u00b1 1.48 mg \u2022 h\/L, which ranged from 4.70 to 9.46 mg \u2022 h\/L. The AUC<jats:sub>1<\/jats:sub>was below the therapeutic concentration of 7.38 mg \u2022 h\/L in 45% (9 of 20) of the patients. The CL<jats:sub>T<\/jats:sub>of 3.05 \u00b1 0.56 mL\/min\/kg was not significantly different with the CL<jats:sub>1<\/jats:sub>of 3.03 \u00b1 0.69 mL\/min\/kg (<jats:italic>P<\/jats:italic>= .901). A sampling scheme at 2 and 6 hours after the test dose was developed to predict the AUC<jats:sub>T<\/jats:sub>(mean prediction error of 1.64%, root mean square error of 6.17%, and absolute mean prediction error of 4.94%). Additionally, the Bland\u2010Altman plot showed that the 2\u2010sampling scheme provided an acceptably accurate prediction of the AUC<jats:sub>1<\/jats:sub>. A test dose with a 2\u2010sampling scheme was sufficient to personalize the initial busulfan dosing in hematopoietic cell transplant recipients.<\/jats:p>","DOI":"10.1002\/jcph.1354","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T16:17:36Z","timestamp":1543940256000},"page":"638-645","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Accurate Prediction of Initial Busulfan Exposure Using a Test Dose With 2\u2010 and 6\u2010Hour Blood Sampling in Adult Patients Receiving a Twice\u2010Daily Intravenous Busulfan\u2010Based Conditioning Regimen"],"prefix":"10.1002","volume":"59","author":[{"given":"Jingjing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Liang","sequence":"additional","affiliation":[{"name":"NeoTrident Co. 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