{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:27:41Z","timestamp":1790692061537,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cannabidiol (CBD) is a highly touted product for many different disorders among the lay press. Numerous CBD products are available, ranging from a US Food and Drug Administration (FDA)\u2010approved product called Epidiolex to products created for medical marijuana dispensaries and products sold in smoke shops, convenience stores, and over the Internet. The legal status of the non\u2013FDA\u2010approved products differs depending on the source of the CBD and the state, while the consistency and quality of the non\u2013FDA\u2010approved products vary markedly. Without independent laboratory verification, it is impossible to know whether the labeled CBD dosage in non\u2013FDA\u2010approved CBD products is correct, that the delta\u20109\u2010tetrahydrocannabinol content is &lt;0.3%, and that it is free of adulteration and contamination. On the Internet, CBD has been touted for many ailments for which it has not been studied, and in those diseases with evaluable human data, it generally has weak or very weak evidence. The control of refractory seizures is a clear exception, with strong evidence of CBD's benefit. Acute CBD dosing before anxiety\u2010provoking events like public speaking and the chronic use of CBD in schizophrenia are promising but not proven. CBD is not risk free, with adverse events (primarily somnolence and gastrointestinal in nature) and drug interactions. CBD has been shown to increase liver function tests and needs further study to assess its impact on suicidal ideation.<\/jats:p>","DOI":"10.1002\/jcph.1387","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T22:35:38Z","timestamp":1549578938000},"page":"923-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":220,"title":["A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential"],"prefix":"10.1002","volume":"59","author":[{"given":"C. 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