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This study evaluated and compared the pharmacokinetic (PK) profiles of UDCA and its conjugates glyco\u2010UDCA (G\u2010UDCA) and tauro\u2010UDCA (T\u2010UDCA) in healthy elderly subjects and younger adults. In this randomized, open\u2010label, 2\u2010treatment, 1\u2010sequence, and parallel study, subjects received 400 or 800\u00a0mg UDCA on day 1, followed by 200\u00a0mg UDCA twice daily for 2\u00a0weeks. Blood samples were obtained up to 24\u00a0hours after the first UDCA dose. Changes in miRNA\u2010122, \u03b3\u2010glutamyl transferase, aspartate aminotransferase, and alanine aminotransferase levels from baseline were assessed to determine the safety and pharmacological effects of UDCA. This study examined the outcomes of 16 elderly subjects and 16 younger adults. Dose\u2010normalized peak concentration of and systemic exposure to UDCA were 2 to 4 times higher, and the corresponding values of G\u2010UDCA and T\u2010UDCA were 1.7 times higher in the elderly subjects than in the younger adults. The subjects in both groups showed multiple peak profiles of UDCA and its conjugates. The miRNA\u2010122 levels and hepatic enzyme test results were within the normal range in the elderly subjects after multiple administration of UDCA. This study is the first to confirm that the PK measurements of UDCA were higher in elderly subjects than in younger adults, which may improve the clinical outcomes of elderly subjects.<\/jats:p>","DOI":"10.1002\/jcph.1409","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T17:59:02Z","timestamp":1552931942000},"page":"1085-1092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetics of Ursodeoxycholic Acid in Elderly Volunteers Compared With Younger Adults in a Korean Population"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-4489","authenticated-orcid":false,"given":"Soyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of 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