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In the majority of cases, the PGx information in labeling is derived from studies in adults. Observed genotype\u2010phenotype relationships in adults may not always be reflective of those in certain pediatric age groups because of the influence of ontogeny. The quantitative data necessary for modeling certain genomic markers in pediatrics is still lacking, and further research focused on generating this is needed. In addition, drug safety research focused on understanding the potential contributions of ontogeny, PGx and other underlying mechanisms to differences in adverse drug reactions between pediatrics and adults is warranted.<\/jats:p>","DOI":"10.1002\/jcph.1488","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T09:32:46Z","timestamp":1568107966000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ontogeny and the Application of Pharmacogenomics to Pediatric Drug Development"],"prefix":"10.1002","volume":"59","author":[{"given":"Dionna","family":"Green","sequence":"first","affiliation":[{"name":"Office of Pediatric Therapeutics Office of the Commissioner U.S. Food and Drug Administration  Silver Spring MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","unstructured":"Guidance for Industry: Drug Safety Information \u2010 FDA's Communication to the Public.Silver Spring MD:US Food Drug Administration; March 2007.https:\/\/www.fda.gov\/media\/71668\/download. 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