{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:57:43Z","timestamp":1779926263982,"version":"3.53.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004776","name":"Faculty of Medicine, Chulalongkorn University","doi-asserted-by":"publisher","award":["RA61\/087"],"award-info":[{"award-number":["RA61\/087"]}],"id":[{"id":"10.13039\/501100004776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 24\u2010hour vancomycin area under the serum concentration\u2010time curve (AUC<jats:sub>24<\/jats:sub>) divided by the minimum inhibitory concentration (MIC) (AUC<jats:sub>24<\/jats:sub>\/MIC) is more closely related to patient outcomes than serum trough concentrations (C<jats:sub>trough<\/jats:sub>). Two\u2010point simplified equations for calculating AUC based on serum peak concentrations (C<jats:sub>peak<\/jats:sub>) and C<jats:sub>trough<\/jats:sub>, named equation A (EqA) and equation B (EqB), have recently been adopted into clinical use for adult pediatric patients. We aimed to find the agreement between predicted AUC<jats:sub>24<\/jats:sub> using the reference method (ref) relative to EqA and EqB and the correlation between C<jats:sub>trough<\/jats:sub> and AUC<jats:sub>24<\/jats:sub>. From June to December 2018, 43 pediatric patients with normal renal function, receiving 15 mg\/kg of vancomycin intravenously every 6 hours, were enrolled. The pediatric patients\u2019 median age was 2.2 years (range 0.1\u201015.3). At steady state, vancomycin C<jats:sub>peak<\/jats:sub> and C<jats:sub>trough<\/jats:sub> were measured at 2 hours after infusion completion and within 30 minutes before the next dosing, respectively. AUC<jats:sub>24<\/jats:sub> was estimated using ref, EqA, and EqB. From Bland\u2010Altman analysis, the 2 AUC<jats:sub>24<\/jats:sub>s estimated by ref and EqA showed less bias than those estimated by ref and EqB (bias 1.3 and \u201372.1 mg\u22c5h\/L, respectively). C<jats:sub>trough<\/jats:sub> and AUC<jats:sub>24<\/jats:sub> using either ref or EqA were correlated more closely (<jats:italic>r<jats:sup>2<\/jats:sup><\/jats:italic> = 0.94) than with EqB (<jats:italic>r<jats:sup>2<\/jats:sup><\/jats:italic> = 0.86). Assuming a vancomycin MIC of 1 mg\/L, an AUC<jats:sub>24<\/jats:sub> \u2265400 mg\u22c5h\/L was targeted. Regardless of the method used, AUC<jats:sub>24<\/jats:sub> \u2265400 mg\u22c5h\/L was never seen with C<jats:sub>trough<\/jats:sub> &lt;8 mg\/L but was always seen with C<jats:sub>trough<\/jats:sub> &gt;10 mg\/L. In conclusion, EqA based on the 2 measured serum concentrations was sufficiently accurate for AUC<jats:sub>24<\/jats:sub> estimation. C<jats:sub>trough<\/jats:sub> &gt;10 mg\/L correlated highly to AUC<jats:sub>24<\/jats:sub> \u2265400 mg\u22c5h\/L.<\/jats:p>","DOI":"10.1002\/jcph.1498","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T04:19:07Z","timestamp":1564028347000},"page":"1597-1605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Optimizing Vancomycin Use Through 2\u2010Point AUC\u2010Based Therapeutic Drug Monitoring in Pediatric Patients"],"prefix":"10.1002","volume":"59","author":[{"given":"Pintip","family":"Suchartlikitwong","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Center of Excellence for Pediatric Infectious Diseases and Vaccines Faculty of Medicine Chulalongkorn University  Bangkok 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