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The study population consisted of 2 groups of men with nonautoimmune hypothyroidism matched for age, weight, insulin sensitivity, and thyrotropin levels. The first group (n = 11) included subjects with low serum testosterone levels, while the second (n = 12) men with testosterone levels within the reference range. Because of concomitant type 2 diabetes, all men were treated with\u00a0metformin\u00a0(2550\u20103000 mg daily). Circulating levels of glucose, prolactin, testosterone, gonadotropins, thyrotropin, and free\u00a0thyroid\u00a0hormones were measured, while the\u00a0structure parameters of thyroid homeostasis\u00a0and the degree of insulin sensitivity were calculated at baseline and 16 weeks later. In both study groups, metformin\u00a0decreased plasma glucose levels and improved insulin sensitivity. However, only in men with low testosterone levels, the drug decreased thyrotropin levels, reduced Jostel's thyrotropin index, and increased SPINA\u2010GT. Metformin\u2010induced changes in thyrotropin and Jostel's index correlated with their baseline values, baseline levels of testosterone, and with the effect of treatment on insulin sensitivity. In men with neither low or normal testosterone levels, metformin affected free thyroid hormones, prolactin, testosterone, gonadotropins, and SPINA\u2010GD. The obtained results suggest that the impact of metformin on thyrotrope function depends on the androgen status of a patient.<\/jats:p>","DOI":"10.1002\/jcph.1507","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T04:00:17Z","timestamp":1565150417000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Impact of Testosterone on Metformin Action on Hypothalamic\u2010Pituitary\u2010Thyroid Axis Activity in Men: A Pilot Study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-2620","authenticated-orcid":false,"given":"Robert","family":"Krysiak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice 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