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Compelling evidence has demonstrated a pivotal role of the exposure level of MPA in determining the rate of allograft rejection as well as the incidence of adverse outcomes, such as gastrointestinal complaints and myelosuppression. Because MPA has wide interindividual pharmacokinetic (PK) variability, the importance of maintaining the MPA concentration levels within its therapeutic range is clear. In addition, due to its complex PKs, MPA is prone to inadvertently develop PK drug\u2010drug interactions (DDIs) with many agents, some of which are commonly used in organ transplant recipients. Failure to acknowledge such clinically significant PK DDIs between MPA and other coadministered drugs could potentially lead to devastating outcomes, ie, the occurrence of acute and chronic allograft rejection or the development of severe adverse events. The rationale to avoid concomitant use of certain drugs with MPA has been established; however, there is a lack of comprehensive literature to guide clinicians and medical professionals on the recognition and monitoring of potential PK DDIs when MPA is prescribed. In this article we comprehensively review, summarize, and discuss previous clinical studies that investigated the impact of coadministered drugs on the PK of MPA, with a major focus on the PK DDIs between MPA and commonly coadministered drugs.<\/jats:p>","DOI":"10.1002\/jcph.1565","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T05:43:31Z","timestamp":1575870211000},"page":"295-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mycophenolic Acid and Its Pharmacokinetic Drug\u2010Drug Interactions in Humans: Review of the Evidence and Clinical Implications"],"prefix":"10.1002","volume":"60","author":[{"given":"Juthipong","family":"Benjanuwattra","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Chiang Mai University  Chiang Mai 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