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Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome\u2013coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that induce intra\u2010alveolar fibrin accumulation that reduces the gas exchange. Therefore, an add\u2010on therapy with drugs able to reduce inflammation, edema, and cell activation has been proposed as well as a treatment with interferon, corticosteroids or monoclonal antibodies (eg, tocilizumab). In this article reviewing literature data related to the use of escin, an agent having potent anti\u2010inflammatory and anti\u2010viral effects in lung injury, we suggest that it could represent a therapeutic opportunity as add\u2010on therapy in ALI related to COVID\u201019 infection.<\/jats:p>","DOI":"10.1002\/jcph.1644","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T07:40:22Z","timestamp":1590133222000},"page":"815-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Severe Acute Lung Injury Related to COVID\u201019 Infection: A Review and the Possible Role for Escin"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-7902","authenticated-orcid":false,"given":"Luca","family":"Gallelli","sequence":"first","affiliation":[{"name":"Department of Health Science University of Catanzaro, Italy and Operative Unit of Clinical Pharmacology 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