{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:34:15Z","timestamp":1782902055685,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The third trimester of pregnancy is related to physiological changes that can modify the process of absorption, distribution, metabolism, and excretion and, consequently, the efficacy and toxicity of drugs. However, little is known about furosemide pharmacokinetics and placental transfer in pregnancy. This study evaluated the maternal\u2010fetal pharmacokinetics and distribution to amniotic fluid of furosemide in hypertensive parturient women under cesarean section. Twelve hypertensive parturient women under methyldopa (250 mg\/8 h) and\/or pindolol (10 mg\/12 h) treatment received a 40\u2010mg single oral dose of furosemide 1 to 10 hours before delivery by cesarean section. Blood and urine samples were collected for 12 hours after furosemide administration. At delivery, samples were obtained from maternal and umbilical cord blood (n = 8) to assess the transplacental transfer. Amniotic fluid (n = 4) was collected at the time of delivery. The following furosemide pharmacokinetic parameters were obtained as median (interquartile range): C<jats:sub>max<\/jats:sub>, 403 ng\/mL (229 to 715 ng\/mL); T<jats:sub>max<\/jats:sub>, 2.00 hours (1.50 to 4.83 hours); elimination half\u2010life (t<jats:sub>1\/2<\/jats:sub>), 2.50 hours (1.77 to 2.97 hours); AUC<jats:sub>0\u201012 h<\/jats:sub>, 1366 ng\u22c5h\/mL (927 to 2531 ng\u22c5h\/mL); AUC<jats:sub>0\u2010\u221e<\/jats:sub>, 1580 ng\u22c5h\/mL (1270 to 2881 ng\u22c5h\/mL); CL\/F 25.3 L\/h (13.8 to 31.4 L\/h); CLR, 2.50 L\/h (1.77 to 2.97 L\/h); CLNR, 22.7 L\/h (12.1 to 25.6 L\/h); and V<jats:sub>d<\/jats:sub>\/F 82.8 L (34.4 to 173 L). The transplacental transfer of furosemide was 0.43 (0.10 to 0.73), and the amniotic fluid concentration was 11.0 ng\/mL (5.51 to 14.6 ng\/mL). From a clinical point of view, these results suggest that substrates of uridine diphosphate\u2010glucuronosyltransferase isoenzymes such as furosemide may have increased clearance during pregnancy and could require dose adjustment in this population.<\/jats:p>","DOI":"10.1002\/jcph.1681","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T19:03:50Z","timestamp":1592679830000},"page":"1655-1661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Pilot Study of the Maternal\u2010Fetal Pharmacokinetics of Furosemide in Plasma, Urine, and Amniotic Fluid of Hypertensive Parturient Women Under Cesarean Section"],"prefix":"10.1002","volume":"60","author":[{"given":"Paulo Vinicius Bernardes","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of 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