{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:39:38Z","timestamp":1787960378277,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our main objective was to investigate the numbers of days necessary for the disappearance of the cough caused by an angiotensin\u2010converting enzyme inhibitor (ACEI) subsequent to the discontinuation of treatment, and to identify the associated factors that contribute to the appearance of said cough and angioneurotic edema. We studied 1101 patients with hypertension treated with an ACEI for 15 years. A multivariate analysis of binary logistic regression was performed to identify predisposing cough factors. In the 1101 patients treated with ACEI, 270 were diagnosed as having a cough caused by an ACEI (24.5%). The average numbers of days until the cough disappeared was 6.06 \u00b1 1.58 days. The significant predisposing factors of the cough were female sex (odds ratio [OR], 1.77; 95% confidence interval [CI], 1.31\u20102.39), previous diagnosis of obstructive sleep apnea (OR, 1.85; 95% CI, 1.31\u20102.61), and concomitant use of thiazides (OR, 1.50; 95% CI, 1.11\u20102.04). Statins were shown as a protective factor (OR, 0.69; 95% CI, 0.51\u20100.93). In the case of angioneurotic edema, 25 patients (2.3%) were diagnosed, without significant determinants. Our analysis showed that the cough disappeared in a period of \u226410 days for 96.7% of patients diagnosed with a cough, subsequent to the discontinuation of ACEI treatment. The risk factors identified for the appearance of a cough include female sex, previous obstructive sleep apnea, and concomitant use of thiazides. The use of statins was found to be a protective factor. The incidence of angioneurotic edema in our cohort is greater than that described in the literature.<\/jats:p>","DOI":"10.1002\/jcph.1786","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T10:09:55Z","timestamp":1605348595000},"page":"591-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Days Needed for the Disappearance of a Cough Due to the Use of an Angiotensin\u2010Converting Enzyme Inhibitor and Identification of Predisposing Factors Associated With Its Appearance in a Clinical Cohort of Hypertensive Patients"],"prefix":"10.1002","volume":"61","author":[{"given":"Manuel","family":"Fernandez\u2010Rando","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen V.","family":"Almeida\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Bioestad\u00edstica Unidad de Investigaci\u00f3n Hospital Universitario de Valme  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Grilo","sequence":"additional","affiliation":[{"name":"Facultad Medicina Universidad Sevilla Jefe Secci\u00f3n M. 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