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The association between the SARS\u2010CoV\u20102 invasion mechanism and the renin\u2010angiotensin\u2010aldosterone system (RAAS) receptors, created many debates about the possible consequences of using RAAS\u2010modulating drugs including angiotensin\u2010converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) during the pandemic. Many clinical studies were conducted to assess the outcomes of coronavirus disease 2019 (COVID\u201019) in patients who use ACEi\/ARBs following the arguments claiming to discontinue these drugs as a precautionary measure. Although several studies mainly analyzed the outcomes of the disease, this review aimed to compare specific blood markers in both groups of COVID\u201019 patients to gain better insight into the interaction of ACEi\/ARBs with different body functions during the infection. Several databases were searched using a combination of keywords followed by screening and data extraction. Only 28 studies met our inclusion criteria, the majority of which showed no significant difference between the inflammation markers of COVID\u201019 patients who used or did not use ACEi\/ARBs. Interestingly, 6 studies reported lower inflammatory markers in COVID\u201019 patients who used ACEi\/ARBs, and 6 studies reported better outcomes among the same group. We therefore concluded that the use of ACEi\/ARBs may not lead to worse prognosis of COVID\u201019 and may even play a protective role against the hyperinflammatory response associated with COVID\u201019.<\/jats:p>","DOI":"10.1002\/jcph.1852","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T16:02:16Z","timestamp":1614355336000},"page":"987-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Interplay Between the Immune System, the Renin\u2010Angiotensin\u2010Aldosterone System (RAAS), and RAAS Inhibitors May Modulate the Outcome of COVID\u201019: A Systematic Review"],"prefix":"10.1002","volume":"61","author":[{"given":"Hiba","family":"Naveed","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine Qatar, Qatar Foundation Education City  Doha 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