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There is a growing body of evidence, obtained from clinical trials and case reports, demonstrating clinical and paraclinical improvement in patients following administration of baricitinib including RA, systemic lupus erythematosus, psoriasis, atopic dermatitis, alopecia areata, interferon\u2010mediated autoinflammatory diseases, graft\u2010versus\u2010host disease, diabetic kidney disease, and, recently, coronavirus disease\u201019. However, despite overall encouraging results, many adverse effects have been observed in baricitinib\u2010treated patients, ranging from simple infections to increased risk of malignancies, particularly in long\u2010term use. The significant efficacy of baricitinib, versus the probable adverse effects, urge further investigation before establishing it as a part of standard therapeutic protocols. Here, we have provided a review of the studies that have used baricitinib for treating various inflammatory disorders and summarized the advantages and disadvantages of its administration.<\/jats:p>","DOI":"10.1002\/jcph.1874","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T04:49:35Z","timestamp":1618807775000},"page":"1274-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Baricitinib: From Rheumatoid Arthritis to COVID\u201019"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-3127","authenticated-orcid":false,"given":"Sara","family":"Assadiasl","sequence":"first","affiliation":[{"name":"Molecular Immunology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Fatahi","sequence":"additional","affiliation":[{"name":"Department of 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