{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:14:14Z","timestamp":1761110054238},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T00:00:00Z","timestamp":1365206400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Inflammation is a strong predictor of increased morbidity and mortality in hemodialysis (HD) patients. Paricalcitol, a selective vitamin D receptor activator used for prevention and treatment of secondary hyperparathyroidism, has shown anti\u2010inflammatory properties in experimental studies, although clinical data are scarce. In an open\u2010label, prospective, single center, pilot study, 25 stable HD patients, previously receiving calcitriol, completed 12 weeks of therapy with oral paricalcitol. Serum and peripheral blood mononuclear cell (PBMC) expression profiles of inflammatory cytokines were analyzed. Serum interleukin (IL)\u20101, IL\u201010, and IL\u201018 did not change, unlike high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and IL\u20106, which experienced a significant mean percent decrease of 14.3%, 4.7%, and 5%, respectively. There was a significant reduction in the TNF\u2010\u03b1\/IL\u201010 and the IL\u20106\/IL\u201010 ratios (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Serum intact parathyroid hormone concentration experienced a mild but significant reduction. In addition, expression levels of TNF\u2010\u03b1 and IL\u20106 decreased by 19.1% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and 17.5% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), respectively, whereas expression of IL\u201010 increased by 17.7% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) after treatment. In conclusion, paricalcitol administration to HD patients is associated with a beneficial effect on the inflammatory cytokine serum and gene expression profile of PBMC. This effect may contribute to the survival benefits of paricalcitol observed in clinical studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcph.19","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T21:28:12Z","timestamp":1361395692000},"page":"421-426","source":"Crossref","is-referenced-by-count":27,"title":["Anti\u2010Inflammatory Profile of Paricalcitol in Hemodialysis Patients: A Prospective, Open\u2010Label, Pilot Study"],"prefix":"10.1002","volume":"53","author":[{"given":"Juan F.","family":"Navarro\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Nephrology Service University Hospital Nuestra Se\u00f1ora de Candelaria Santa Cruz de Tenerife Spain"},{"name":"Research Unit University Hospital Nuestra Se\u00f1ora de Candelaria Santa Cruz de Tenerife Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol para el Estudio de la Nefropat\u00eda 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