{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:11:11Z","timestamp":1787238671303,"version":"build-2736575974"},"reference-count":157,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The public health crisis of pregnant women being exposed to drugs of abuse and of its impact on their unborn children continues to grow at an alarming rate globally. The state of pregnancy is unique, with physiological changes that can lead to changes in the way drugs are handled by the body in both pharmacokinetics and response. These changes place the pregnant woman, fetus, and newborn infant at risk, as many of these drugs can cross the placenta and into breast milk. The substances most commonly linked to harmful effects include alcohol, tobacco, cannabis, stimulants, and opioids. The pharmacological and toxicological changes caused by in utero exposure or breastfeeding exposure are difficult to study, and the full extent of the mechanisms involved are not fully understood. However, these changes can significantly affect the risks of substance abuse and influence optimal treatment of pregnant women with a substance use disorder. In addition, newborns who were exposed to drugs of abuse in utero can experience withdrawal syndromes. Pharmacological management in infants is used to guide and treat withdrawal symptoms, with the goal being to improve the infant's sleep, eating, and comfort. Several barriers may prevent pregnant women from seeking help for substance use, including stigma and interactions with the legal system. Understanding changes in pharmacology, including pharmacokinetic changes that happen during pregnancy, is essential for anticipating the extent of maternal exposure and neonatal adverse effects.<\/jats:p>","DOI":"10.1002\/jcph.1928","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T02:34:25Z","timestamp":1629081265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Maternal Exposure and Neonatal Effects of Drugs of Abuse"],"prefix":"10.1002","volume":"61","author":[{"given":"Jessica M.","family":"Barry","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota, Minnesota  Minneapolis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela K.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota, Minnesota  Minneapolis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Jasin","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Dayton Children's Hospital  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0844-3207","authenticated-orcid":false,"given":"Catherine M.","family":"Sherwin","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota, Minnesota  Minneapolis USA"},{"name":"Department of Pediatrics Wright State University, Boonshoft School of Medicine, Dayton Children's Hospital  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,15]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"National Institute of Drug Abuse. Substance Use While Pregnant and Breastfeeding.https:\/\/www.drugabuse.gov\/publications\/research\u2010reports\/substance\u2010use\u2010in\u2010women\/substance\u2010use\u2010while\u2010pregnant\u2010breastfeeding. Published2021. Accessed May 10 2021."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.5.566"},{"key":"e_1_2_13_4_1","volume-title":"Substance\u2010Exposed Infants: State Responses to the Problem","author":"Young NK","year":"2009"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-4070"},{"key":"e_1_2_13_6_1","unstructured":"Centers for Disease Control and Prevention. About Opioid Use During Pregnancy.https:\/\/www.cdc.gov\/pregnancy\/opioids\/basics.html. Published2020. Accessed January 28 2021."},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40352-015-0015-5"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1875436"},{"key":"e_1_2_13_9_1","article-title":"Perinatal Drug Abuse and Neonatal Drug Withdrawal","author":"Wang M","year":"2020","journal-title":"Medscape"},{"key":"e_1_2_13_10_1","unstructured":"Pregnancy 2021 Centers for Disease Control and Prevention"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-00893-8"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.07.006"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0035-5"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6801a2"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12642"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2009.09.012"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2017.11.010"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnu.12609"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2021.106975"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.36"},{"key":"e_1_2_13_21_1","unstructured":"American College of Obstetricians and Gynecologists.Opioid use and opioid use disorder in pregnancy.https:\/\/www.acog.org\/clinical\/clinical-guidance\/committee-opinion\/articles\/2017\/08\/opioid-use-and-opioid-use-disorder-in-pregnancy. Published2017. Accessed January 28 2021."},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-019-0807-5"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.03923.x"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17062034"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.273"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr022"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199733050-00002"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00065"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13642"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00001"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.1"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1973.tb16051.x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.11.2249"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1988.tb05423.x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91054-G"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563659809162576"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1993.29"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-3289(20)30008-0"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000398"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.06.029"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1427"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.09.095"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/187231209788654117"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.01.012"},{"issue":"2","key":"e_1_2_13_45_1","first-page":"F338","article-title":"Altered glomerular permselectivity to neutral dextrans and heteroporous membrane modeling in human pregnancy","volume":"270","author":"Roberts M","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.049015"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.046276"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0937-5"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.014"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(92)90005-D"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.11.029"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90424-6"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb21025.x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90646-O"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481008"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69248-5_2"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016568"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13029"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13050680"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.09.021"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2009.12.044"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318195d7cb"},{"issue":"10","key":"e_1_2_13_63_1","first-page":"988","article-title":"Detection of cocaine exposure in the neonate. Analyses of urine, meconium, and amniotic fluid from mothers and infants exposed to cocaine","volume":"118","author":"Casanova OQ","year":"1994","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<115::AID-CNE10>3.0.CO;2-X"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj070125"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199911080-00034"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.03.035"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2006.01457.x"},{"key":"e_1_2_13_69_1","unstructured":"Substance Abuse and Mental Health Services Administration.Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health (HHS Publication No. PEP20\u201007\u201001\u2010001 NSDUH Series H\u201055).Rockville MD:Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration.https:\/\/www.samhsa.gov\/data\/. Published2020. Accessed May 10 2021."},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3995fje"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25509"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.66.2.204"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2006.09.009"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1104"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod55.4.756"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2011.563336"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595239600185691"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10166"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.742"},{"key":"e_1_2_13_80_1","unstructured":"National Center on Substance Abuse and Child Welfare. Children and Families Affected by Parental Substance Use Disorders (SUDs).https:\/\/ncsacw.samhsa.gov\/topics\/parental-substance-use-disorder.aspx. Accessed January 28 2021."},{"key":"e_1_2_13_81_1","volume-title":"Communities in Action: Pathways to Health Equity","author":"National Academies of Sciences Engineering and Medicine, Health and Medicine Division, Board on Population Health and Public Health Practice","year":"2017"},{"key":"e_1_2_13_82_1","volume-title":"Substance Abuse Treatment: Addressing the Specific Needs of Women","author":"Center for Substance Abuse Treatment","year":"2009"},{"key":"e_1_2_13_83_1","unstructured":"Royal College of Obstetricians & Gynaecologists.Medical terms explained.https:\/\/www.rcog.org.uk\/en\/patients\/medical-terms\/. Published2021. Accessed January 28 2021."},{"issue":"1","key":"e_1_2_13_84_1","first-page":"57","article-title":"Prenatal tobacco, marijuana, stimulant, and opiate exposure: outcomes and practice implications","volume":"6","author":"Minnes S","year":"2011","journal-title":"Addict Sci Clin Pract"},{"issue":"2","key":"e_1_2_13_85_1","first-page":"06","article-title":"Maternal substance use: consequences, identification, and interventions","volume":"40","author":"Chang G","year":"2020","journal-title":"Alcohol Res"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009986"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0576-6"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.09.014"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.827"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.04.033"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000472"},{"key":"e_1_2_13_92_1","unstructured":"World Health Organization.Guidelines for the identification and management of substance use and substance use disorders in pregnancy.https:\/\/www.who.int\/publications\/i\/item\/9789241548731. Published2014. Accessed January 28 2021."},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03120.x"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000427"},{"key":"e_1_2_13_95_1","unstructured":"American Society of Addiction Medicine.The ASAM National Practice Guideline for the treatment of opioid use disorder: 2020 focused update.https:\/\/www.asam.org\/docs\/default-source\/quality-science\/npg-jam-supplement.pdf?sfvrsn=a00a52c2_2. Published 2020. Accessed January 28 2021."},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000635"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.02.010"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.011"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21132"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800408330395"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.06.022"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01321.x"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000092"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1049-9"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.10.004"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03440.x"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.04042.x"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.109103"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1693689"},{"key":"e_1_2_13_110_1","first-page":"CD010078","article-title":"Pharmacological interventions for promoting smoking cessation during pregnancy","volume":"3","author":"Claire R","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00446"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1177\/002204260203200103"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000503"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4603(02)00259-9"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1521\/bumc.2014.78.3.243"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23541"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15185"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2011.00119.x"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000418"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1018821"},{"issue":"4","key":"e_1_2_13_121_1","first-page":"545","article-title":"Cocaine intoxication presenting as preeclampsia and eclampsia","volume":"81","author":"Towers CV","year":"1993","journal-title":"Obstet Gynecol"},{"issue":"3","key":"e_1_2_13_122_1","first-page":"230","article-title":"Cocaine intoxication associated with abruptio placentae","volume":"83","author":"Flowers D","year":"1991","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e67094"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2012.02.001"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(95)01102-5"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950030013002"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v13n04_07"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820110052008"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.05.021"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199506000-00004"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.10.011"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06111851"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4603(97)00020-8"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3212"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-029074"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2019.00814"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2019-0087"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2017-0128"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-4036"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1141"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3835"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1608634"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.1307"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.11.013"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.08.024"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015908784533842"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu190"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0978"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.041"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.088"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222550499"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002083220604"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2015.9992"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.155.7.765"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2015.29002"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077559507300322"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.10.004"},{"issue":"1","key":"e_1_2_13_158_1","first-page":"41","article-title":"The legality of drug\u2010testing procedures for pregnant women","volume":"10","author":"Pulatie K","year":"2008","journal-title":"Virtual Mentor"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.1928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcph.1928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.1928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T01:11:57Z","timestamp":1693271517000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.1928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":157,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/jcph.1928"],"URL":"https:\/\/doi.org\/10.1002\/jcph.1928","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"2021-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}