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This meta\u2010analysis has evaluated the efficacy and safety of lasmiditan for the treatment of acute migraine in adults. After performing a literature search on MEDLINE\/PubMed, Scopus, Cochrane databases, and International Clinical Trial Registry Platform, reviewers assessed eligibility and extracted data from 4 relevant articles. Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis guidelines were followed in the selection, analysis, and reporting of findings. A random\u2010effects model was used to estimate effect size. Quality assessment was done using the risk of bias assessment tool and meta\u2010regression for probable variables affecting effect size. Subgroup analysis was done depending on the dose of lasmiditan. Lasmiditan use was associated with a significantly higher percentage of patients with pain freedom (odds ratio [OR], 2.02; 95% confidence interval [CI], 1.72\u20102.39; <jats:italic>P<\/jats:italic> &lt; .00001), sustained pain freedom (OR, 1.93; 95%CI, 1.55\u20102.39; <jats:italic>P<\/jats:italic> &lt;.00001), headache response (OR, 2.05; 95%CI, 1.77\u20102.36; <jats:italic>P<\/jats:italic> &lt; .00001), clinical disability level (OR, 1.36; 95%CI, 1.20\u20101.55; <jats:italic>P<\/jats:italic> &lt; .00001), patients\u2019 global impression (OR, 1.88; 95%CI, 1.69\u20102.10; <jats:italic>P<\/jats:italic> &lt; .00001), and significantly lower use of rescue medication (OR, 0.49; 95%CI, 0.38\u20100.63; <jats:italic>P<\/jats:italic> &lt; .00001) compared to placebo. Lasmiditan use was also associated with a higher likelihood of adverse effects like dizziness (OR, 6.54; 95%CI, 4.24\u201010.07; <jats:italic>P<\/jats:italic> &lt; .00001), paresthesia (OR, 4.28; 95%CI, 2.97\u20106.17; <jats:italic>P<\/jats:italic> &lt; .00001), and fatigue (OR, 5.67; 95%CI, 3.78\u20108.52; <jats:italic>P<\/jats:italic> &lt; .00001) compared to placebo. Subgroup analysis showed a dose\u2010dependent effect of lasmiditan on pain freedom, sustained pain freedom, patient's global impression, and occurrence of adverse drug reactions. Prediction probability for effect estimate favoring placebo was calculated to be 0.0017%. Lasmiditan has shown a favorable effect in terms of efficacy and safety in the treatment of an acute attack of migraine in comparison to placebo. Further studies are needed to evaluate long\u2010term safety, efficacy, and use in specific subgroups of patients.<\/jats:p><jats:p>PROSPERO Registration Number: CRD42020177838<\/jats:p>","DOI":"10.1002\/jcph.1962","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T07:20:21Z","timestamp":1630567221000},"page":"1534-1544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Safety of Lasmiditan for Acute Treatment of Migraine in Adults: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-9178","authenticated-orcid":false,"given":"Rituparna","family":"Maiti","sequence":"first","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences (AIIMS)  Bhubaneswar Odisha 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