{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:18:57Z","timestamp":1747149537416,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angiotensin\u2010converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) drugs may modify risk associated with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). Therefore, we assessed whether baseline therapy with ACEIs or ARBs was associated with lower mortality, respiratory failure (noninvasive ventilation or intubation), and renal failure (new renal replacement therapy) in SARS\u2010CoV\u20102\u2010positive patients. This retrospective registry\u2010based observational cohort study used data from a national database of emergency department patients tested for SARS\u2010CoV\u20102. Symptomatic emergency department patients were accrued from January to October 2020, across 197 hospitals in the United States. Multivariable analysis using logistic regression evaluated end points among SARS\u2010CoV\u20102\u2013positive cases, focusing on ACEIs\/ARBs and adjusting for covariates. Model performance was evaluated using the <jats:italic>c<\/jats:italic> statistic for discrimination and Cox plotting for calibration. A total of 13\u00a0859 (99.9%) patients had known mortality status, of whom 2045 (14.8%) died. Respiratory failure occurred in 2485\/13\u00a0880 (17.9%) and renal failure in 548\/13\u00a0813 (4.0%) patients with available data. ACEI\/ARB status was associated with a 25% decrease in mortality odds (odds ratio [OR], 0.75; 95%CI, 0.59\u20100.94; <jats:italic>P<\/jats:italic> = .011; <jats:italic>c<\/jats:italic> = .82). ACEIs\/ARBs were not significantly associated with respiratory failure (OR, 0.89; 95%CI, 0.78\u20101.06; <jats:italic>P<\/jats:italic> = .206) or renal failure (OR, 0.75; 95%CI, 0.55\u20101.04; <jats:italic>P<\/jats:italic> = .083). Adjusting for covariates, baseline ACEI\/ARB was associated with 25% lower mortality in SARS\u2010CoV\u20102\u2013positive patients. The potential mechanism for ACEI\/ARB mortality modification requires further exploration.<\/jats:p>","DOI":"10.1002\/jcph.2015","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T14:54:06Z","timestamp":1639839246000},"page":"777-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Baseline Use of Angiotensin\u2010Converting Enzyme Inhibitors and Angiotensin\u00a0Receptor Blockers and Death Among Patients Tested for COVID\u201019"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-5416","authenticated-orcid":false,"given":"Sarah A.","family":"Thomas","sequence":"first","affiliation":[{"name":"BSc Medical Biosciences Candidate Faculty of Medicine Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Puskarich","sequence":"additional","affiliation":[{"name":"Hennepin Healthcare  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Pulia","sequence":"additional","affiliation":[{"name":"Departments of Emergency Medicine and Industrial and Systems Engineering University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"GWU School of Medicine &amp; Health Sciences Department of Emergency Medicine  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Mark","family":"Courtney","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen E.","family":"Nordenholz","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Kabrhel","sequence":"additional","affiliation":[{"name":"Center for Vascular Emergencies Department of Emergency Medicine, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003138117"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr2005760"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2020-001424"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1267"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102907"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03120-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.04.037"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01248-09"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03730-2020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1643-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.510461"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317393"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1624"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab124"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317134"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/emp2.12313"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118548387"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-008-7068-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg074"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2021.1916947"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30558-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202902"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-0476-3"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.2015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcph.2015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:46:58Z","timestamp":1693007218000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/jcph.2015"],"URL":"https:\/\/doi.org\/10.1002\/jcph.2015","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"type":"print","value":"0091-2700"},{"type":"electronic","value":"1552-4604"}],"subject":[],"published":{"date-parts":[[2022,2,8]]},"assertion":[{"value":"2021-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}