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A total of 477 patients receiving double antiaggregation therapy with aspirin and clopidogrel, after suffering a first event, were followed for 1 year to record relapse, as a surrogate end point to measure their therapeutic response, as defined by presenting with an acute coronary event (unstable angina, ST\u2010segment\u2013elevation myocardial infarction, or non\u2013ST\u2010segment\u2013elevation myocardial infarction), stent thrombosis\/restenosis, or cardiac mortality. Anthropometric, clinical, and pharmacological variables along with <jats:italic>CYP2C19<\/jats:italic> genotypes were analyzed for their association with the disease relapse phenotype. Only 75 patients (15%) suffered a relapse, which occurred during the first 6\u00a0months of therapy, with a peak at 4.5 months. An initial univariate analysis identified that patients in the relapse group were significantly older (67.4 \u00b1 11.0 vs 61.6 \u00b1 12.3 years old) and presented with diffuse coronary disease, insulin\u2010dependent type 2 diabetes mellitus dyslipidemia, and arterial hypertension. A poor clinical response to the platelet antiaggregation regime also occurred more frequently among patients taking acenocoumarol and calcium channel blockers, along with aspirin and clopidogrel, while no association was found according to <jats:italic>CYP2C19<\/jats:italic> genotypes. A retrospective multivariate analysis indicated that patients belonging to the nonresponder phenotype to treatment with aspirin and clopidogrel were older, presented with diffuse coronary disease, a group largely overlapping with type 2 insulin\u2010dependent diabetes mellitus, and were taking dihidropyrimidinic calcium channel blockers.<\/jats:p>","DOI":"10.1002\/jcph.2016","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T19:53:50Z","timestamp":1640634830000},"page":"783-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Pharmacological Parameters Determine Relapse During Clopidogrel Treatment of Acute Coronary Syndrome"],"prefix":"10.1002","volume":"62","author":[{"given":"Marta","family":"Santana\u2010Mateos","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Las Palmas de Gran Canaria  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