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These drugs have been proposed to have a beneficial effect on cognition, sleep\u2010related problems, and other affective symptoms in patients with depression. Previous studies have shown inconsistent evidence and have not reported a pooled effect of the 2 drugs of this class: aripiprazole and brexpiprazole. This meta\u2010analysis evaluated the effect of augmentation with SDAM drugs in patients with major depression. The meta\u2010analysis protocol was made as per Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis Protocol guidelines and registered in the International Prospective Register of Ongoing Systematic Reviews. The PubMed\/MEDLINE, Cochrane Clinical Trial registry, and EudraCT databases were searched with prespecified search terms. A random\u2010effects meta\u2010analysis was performed using the meta package in R software. Fifteen studies were included in this meta\u2010analysis. The random\u2010effects model analysis observed a pooled effect of 1.55 (95%CI, 1.32\u20101.84; prediction interval, 0.95\u20102.55, <jats:italic>z<\/jats:italic> = 5.19 [<jats:italic>P<\/jats:italic> &lt; .0001]) for remission between the SDAM and placebo groups. A pooled effect of 1.58 (95%CI, 1.37\u20101.83; prediction interval, 1.00\u20132.51, <jats:italic>z<\/jats:italic> = 6.34 [<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001]) for adverse events and 0.72 (95%CI, 0.48\u20101.08; prediction interval, 0.46\u20101.12; <jats:italic>z<\/jats:italic> = \u22121.58 [<jats:italic>P<\/jats:italic> = .113]) for serious adverse events was observed. No significant publication bias was noticed. The quality of the evidence was rated as high. Adjunct SDAM increased remission in patients and had no significant effect on serious adverse events compared to placebo. Therefore, we conclude that SDAM drugs can be an effective and safe antidepressant augmentation strategy in patients with major depressive disorder.<\/jats:p>","DOI":"10.1002\/jcph.2022","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T13:57:54Z","timestamp":1640872674000},"page":"721-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy and Safety of Adjunctive Serotonin\u2010Dopamine Activity Modulators in Major Depression: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"62","author":[{"given":"Archana","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir Chandra","family":"Sarangi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-9178","authenticated-orcid":false,"given":"Rituparna","family":"Maiti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KH","family":"Reeta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61415-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00231-2"},{"issue":"7","key":"e_1_2_9_5_1","first-page":"42","article-title":"An evidence\u2010based approach to augmentation and combination strategies for: treatment\u2010resistant depression","volume":"3","author":"Barowsky J","year":"2006","journal-title":"Psychiatry"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12615"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"937","article-title":"Augmentation treatment in major depressive disorder: focus on aripiprazole","volume":"4","author":"Nelson JC","year":"2008","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"7","key":"e_1_2_9_8_1","first-page":"418","article-title":"Brexpiprazole (Rexulti): a new monotherapy for schizophrenia and adjunctive therapy for major depressive disorder","volume":"41","author":"Eaves S","year":"2016","journal-title":"P T"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125315614739"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2009.05.005"},{"issue":"12","key":"e_1_2_9_11_1","article-title":"Second\u2010generation antipsychotics for major depressive disorder and dysthymia","author":"Komossa K","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.2009.23.2.156"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_9_18_1","unstructured":"Free statistics calculators. 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