{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:30:06Z","timestamp":1778005806903,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated whether effervescent paracetamol, as an important source of nondietary sodium and fluid load, is associated with a transient increase in the risk of hospitalization for acute heart failure (AHF). We conducted a unidirectional case\u2010crossover study using data from the 1 in 97th representative sample from the French health care database. Subjects aged \u226518 years, hospitalized for AHF during the 2014\u20102016 period, were included. Exposure to effervescent paracetamol was compared between a risk period (ie, 15 days immediately before admission for AHF) and 3 earlier 15\u2010day control periods, to test a possible trigger effect of effervescent paracetamol intake on AHF. Adjusted odds ratios (aORs) were estimated with a conditional logistic regression. We identified 4301 patients hospitalized for AHF. We found that 5.7% of AHF subjects were exposed to effervescent paracetamol during the risk period, as compared with 4.1% during the control periods (aOR, 1.56 [95% confidence interval [CI], 1.27\u20101.90]; <jats:italic>P<\/jats:italic> &lt; .001). This association was also found in the subgroup of subjects with hypertension (aOR, 1.45 [95%CI, 1.13\u20101.87]; <jats:italic>P<\/jats:italic> = .004, n = 2648) and in the subgroup of subjects aged \u226583 years (aOR, 1.70 [95%CI: 1.28\u20102.24], <jats:italic>P<\/jats:italic> &lt; .001, n = 2238). A similar analysis, considering exposure to noneffervescent paracetamol, did not support the existence of an indication bias likely to explain the association observed for effervescent paracetamol. This study suggests an association between effervescent paracetamol and admission for AHF and should be confirmed with other complementary study designs.<\/jats:p>","DOI":"10.1002\/jcph.2027","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T13:40:10Z","timestamp":1642340410000},"page":"883-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Exposure to Effervescent Paracetamol and Hospitalization for Acute Heart Failure: A Case\u2010Crossover Study"],"prefix":"10.1002","volume":"62","author":[{"given":"Germain","family":"Perrin","sequence":"first","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris D\u00e9partement de Pharmacie H\u00f4pital europ\u00e9en Georges\u2010Pompidou  Paris France"},{"name":"Inserm, Cordeliers Research Centre Universit\u00e9 de Paris, Sorbonne Universit\u00e9  Paris France"},{"name":"HeKA  Inria, Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armelle","family":"Arnoux","sequence":"additional","affiliation":[{"name":"INSERM Centre d'Investigation Clinique 1418 \u00c9pid\u00e9miologie Clinique  Paris France"},{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris H\u00f4pital europ\u00e9en Georges\u2010Pompidou Unit\u00e9 de Recherche Clinique from the Georges Pompidou European Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Berdot","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris D\u00e9partement de Pharmacie H\u00f4pital europ\u00e9en Georges\u2010Pompidou  Paris France"},{"name":"Inserm, Cordeliers Research Centre Universit\u00e9 de Paris, Sorbonne Universit\u00e9  Paris France"},{"name":"HeKA  Inria, Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Katsahian","sequence":"additional","affiliation":[{"name":"Inserm, Cordeliers Research Centre Universit\u00e9 de Paris, Sorbonne Universit\u00e9  Paris France"},{"name":"HeKA  Inria, Paris France"},{"name":"INSERM Centre d'Investigation Clinique 1418 \u00c9pid\u00e9miologie Clinique  Paris France"},{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris H\u00f4pital europ\u00e9en Georges\u2010Pompidou Unit\u00e9 de Recherche Clinique from the Georges Pompidou European Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Danchin","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris D\u00e9partement de Cardiologie H\u00f4pital europ\u00e9en Georges\u2010Pompidou  Paris France"},{"name":"Universit\u00e9 de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Sabatier","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris D\u00e9partement de Pharmacie H\u00f4pital europ\u00e9en Georges\u2010Pompidou  Paris France"},{"name":"Inserm, Cordeliers Research Centre Universit\u00e9 de Paris, Sorbonne Universit\u00e9  Paris France"},{"name":"HeKA  Inria, Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.8.847"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000426"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180634"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.04.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6954"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001733"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022368"},{"key":"e_1_2_10_11_1","unstructured":"Open Medic: base compl\u00e8te sur les d\u00e9penses de m\u00e9dicaments interr\u00e9gimes.https:\/\/www.data.gouv.fr\/fr\/datasets\/open-medic-base-complete-sur-les-depenses-de-medicaments-interregimes\/. 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Considering sodium content of medicines.https:\/\/www.sps.nhs.uk\/articles\/considering-sodium-content-of-medicines\/. Published 2021. 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