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This meta\u2010analysis aimed to evaluate the reliability and efficacy of dexmedetomidine as a local anesthetic adjunct for pediatric surgeries. Eligible studies were searched in Cochrane, Embase, PubMed, and CBM. RevMan\u00a05.4 was used to assess the risk of bias of each study and perform statistical analysis. Stata\u00a015.0 was used to evaluate the publication bias of primary outcomes. Thirteen randomized controlled trial (RCTs) involving 722 patients aged 6\u00a0months to 12\u00a0years were harvested. Statistical analysis showed that dexmedetomidine resulted in: a significantly longer duration of analgesia (standardized mean difference [SMD], 7.16; 95% confidence interval [95%CI], 4.88 to 9.43; <jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.001; I<jats:sup>2<\/jats:sup>\u00a0=\u00a098%); a reduction in the 1\u2010hour pain score (mean difference [MD], \u20130.27; 95%CI, \u20130.47 to \u20130.06; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.01; I<jats:sup>2<\/jats:sup>\u00a0=\u00a028%); cumulative doses of rescue analgesic required of 2 doses (risk ratio [RR], 0.26; 95%CI, 0.14 to 0.49; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; I<jats:sup>2<\/jats:sup>\u00a0=\u00a00) or 3 doses (RR, 0.04; 95%CI, 0.01 to 0.16; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; I<jats:sup>2<\/jats:sup>\u00a0=\u00a04%); the frequency of emergence agitation (RR, 0.44; 95%CI, 0.22 to 0.91; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.03; I<jats:sup>2<\/jats:sup>\u00a0=\u00a00); and a reduction in the onset time of blocks (mean difference \u20133.56; 95%CI, \u20136.39 to \u20130.74; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.01; I<jats:sup>2<\/jats:sup>\u00a0=\u00a090%). However, the incidence of some side effects, including hypotension, bradycardia, nausea and vomiting, pruritis, urinary retention, and respiratory depression, did not significantly differ between the dexmedetomidine group and the placebo group. Therefore, dexmedetomidine is a reliable and efficient adjunct to local anesthetics in children.<\/jats:p>","DOI":"10.1002\/jcph.2039","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T11:28:15Z","timestamp":1645961295000},"page":"935-947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Efficacy of Dexmedetomidine as a Local Anesthetic Adjuvant in Children: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-2645","authenticated-orcid":false,"given":"Yan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 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