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The study included 3 groups of women with autoimmune subclinical hypothyroidism matched for thyroid antibody titers and hormone levels: patients receiving atorvastatin (group A) or metformin (group B) and statin\u2010 and metformin\u2010na\u00efve women (group C). Over the entire study period (6 months), all individuals received levothyroxine. Titers of thyroid antibodies, as well as concentrations of thyrotropin, free thyroid hormones, prolactin, lipids, glucose, insulin, high\u2010sensitivity C\u2010reactive protein (hsCRP), and 25\u2010hydroxyvitamin D were assessed at baseline and 6 months later. At baseline, the study groups differed in plasma lipids, insulin sensitivity, and hsCRP. In all groups of patients, levothyroxine decreased thyroid antibody titers, reduced thyrotropin levels and increased free thyroid hormone levels. Treatment\u2010induced changes in antibody titers and free thyroid hormone levels were strongest in group A, while the changes in thyrotropin were most pronounced in group B. The decrease in antibody titers correlated to a greater degree with hsCRP levels than with insulin sensitivity. The obtained results suggest that low\u2010grade systemic inflammation is a more important factor determining the impact of levothyroxine on thyroid autoimmunity and thyroid hormone levels than insulin resistance.<\/jats:p>","DOI":"10.1002\/jcph.2123","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T07:34:37Z","timestamp":1658216077000},"page":"1566-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thyroid Antibody Titers and Hypothalamic\u2010Pituitary\u2010Thyroid Axis Activity in Levothyroxine\u2010Treated Women With Autoimmune Subclinical Hypothyroidism Receiving Atorvastatin or Metformin"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-2620","authenticated-orcid":false,"given":"Robert","family":"Krysiak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Kowalcze","sequence":"additional","affiliation":[{"name":"Department of Pediatrics in Bytom School of Health Sciences in Katowice Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogus\u0142aw","family":"Okopie\u0144","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3280113d1a"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30726-3_17"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.578909"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01941"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2015.11.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.07.019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2018.1541314"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-113872"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1081500"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0273"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.373"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-16-0450"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04042.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2020.1789969"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13532"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3283398e53"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1659133"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154892"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14636"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2008.08.001"},{"key":"e_1_2_9_22_1","first-page":"51","article-title":"A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients. 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