{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T04:45:55Z","timestamp":1692593155652},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune\ncheckpoint inhibitors (ICIs) have been established as the cornerstone for advanced non\u2010small cell lung cancer, while thyroid adverse events (AEs) associated with ICIs have not been systematically documented. Therefore, we performed a meta\u2010analysis to evaluate the effect of ICI applications on the thyroid of patients with non\u2010small cell lung cancer. We performed a systematic search of PubMed, the Cochrane Library, Web of Science, and Embase for eligible randomized controlled trials up to December 2021. Clinical trials reporting thyroid AEs including hypothyroidism, hyperthyroidism, and thyroiditis were enrolled. The <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0statistic was also calculated to quantify the\u00a0heterogeneity. Data were evaluated as risk ratio (RR) and corresponding 95%CIs. A total of 10 randomized clinical trials involving 6154 patients were included in this meta\u2010analysis. ICI application was found to have a statistically significant higher risk of all grade hypothyroidism (RR, 7.03; <jats:italic>P<\/jats:italic> &lt; 0.0001), hyperthyroidism (RR, 4.88; <jats:italic>P<\/jats:italic> &lt; 0.0001), and thyroiditis (RR, 6.58; <jats:italic>P<\/jats:italic> = 0.0014) compared with the chemotherapy group. Moreover, we demonstrated that second\u2010line therapy significantly increased the risk of all\u2010grade hypothyroidism (RR, 7.03 [95%CI, 4.69\u201310.55]) and hyperthyroidism (RR, 4.88 [95%CI, 3.11\u20137.65]). Our meta\u2010analysis manifested that regimens with ICIs may significantly increase all grades of hypothyroidism, hyperthyroidism, and thyroiditis. ICIs may induce the occurrence and exacerbation of endocrine AEs compared with chemotherapy.<\/jats:p>","DOI":"10.1002\/jcph.2150","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T20:41:22Z","timestamp":1662756082000},"page":"210-218","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thyroid Dysfunction in Non\u2010Small Cell Lung Cancer With Immune Checkpoint Inhibitors: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"63","author":[{"given":"Lanlan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Fujian Medical University Union Hospital  Fuzhou 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