{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:56Z","timestamp":1786978016954,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303142\/2019\u20107"],"award-info":[{"award-number":["303142\/2019\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/23938\u20102"],"award-info":[{"award-number":["2016\/23938\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/05616\u20103"],"award-info":[{"award-number":["2018\/05616\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study evaluates the influence of pregnancy and HIV infection in conjunction with the use of raltegravir, lamivudine, and tenofovir disoproxil fumarate (combined antiretroviral therapy [cART]) on intestinal P\u2010glycoprotein (P\u2010gp) and hepatic organic anion transporter polypeptide (OATP) 1B1\/1B3 and\/or breast cancer resistance protein (BCRP) drug transporter activity using rosuvastatin (OATP1B\/BCRP) and fexofenadine (P\u2010gp) probes. Single oral doses of 5\u2010mg rosuvastatin and 60\u2010mg fexofenadine were administered to women living with HIV under cART in the third trimester of gestation (n = 15) and postpartum period (n = 10). A control group of 12 healthy nonpregnant women also was investigated. Pharmacokinetic parameters were estimated by using a noncompartmental method and evaluated by\n                    <jats:italic>t<\/jats:italic>\n                    test (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). The rosuvastatin area under the plasma concentration\u2013time curve from time 0 to the last quantifiable concentration (AUC\n                    <jats:sub>0\u2010last<\/jats:sub>\n                    ) value was higher in the third trimester of pregnancy (19.5 [95%CI, 16.8\u201322.3] ng \u2022 h\/mL] when compared to postpartum (13.3 [95%CI, 9.3\u201317.5] ng \u2022 h\/mL), while the fexofenadine AUC\n                    <jats:sub>0\u2010last<\/jats:sub>\n                    values did not differ between the third trimester of pregnancy (738.0 [95%CI, 611.4\u2013864.6] ng \u2022 h\/mL) and postpartum period (874.9 [95%CI, 408.2\u20131342.0] ng\u2022 h\/mL). The rosuvastatin AUC\n                    <jats:sub>0\u2010last<\/jats:sub>\n                    values did not differ between healthy nonpregnant women (13.8 [95%CI, 10.0\u201317.6] ng \u2022 h\/mL) and women living with HIV in the postpartum period (13.3 [95%CI, 9.3\u201317.5] ng \u2022 h\/mL), and the fexofenadine AUC\n                    <jats:sub>0\u2010last<\/jats:sub>\n                    values did not differ between the 2 investigated groups (603.6 [95%CI, 467.5\u2013739.7] ng \u2022 h\/mL vs 874.9 [95%CI, 408.2\u20131342.0] ng \u2022 h\/mL). It is suggested that gestation inhibits the hepatic OATP1B1\/1B3 and\/or BCRP activity but does not alter intestinal P\u2010gp activity. The influence of HIV infection in conjunction with use of cART on OATP1B\/BCRP and intestinal P\u2010gp activity was not observed.\n                  <\/jats:p>","DOI":"10.1002\/jcph.2152","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T10:43:13Z","timestamp":1662806593000},"page":"219-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["P\u2010Glycoprotein and Organic Anion Transporter Polypeptide 1B\/Breast Cancer Resistance Protein Drug Transporter Activity in Pregnant Women Living With HIV"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-2665","authenticated-orcid":false,"given":"Fernanda de Lima","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"Department of Drugs and Medicines Faculty of Pharmacy Federal University of Rio de Janeiro, Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Pereira dos Santos","family":"Melli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paula","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-4252","authenticated-orcid":false,"given":"Glauco Henrique Balthazar","family":"Nardotto","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo 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