{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:20:38Z","timestamp":1773832838363,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal dysfunction is associated with increased mortality and length of hospital stay in critically ill patients. However, it remains unclear whether the early administration of an angiotensin\u2010converting enzyme inhibitor (ACEI)\/angiotensin receptor blocker (ARB) for intensive care unit patients with renal dysfunction is associated with reduced in\u2010hospital mortality. We conducted a retrospective analysis of critically ill patients who received early administration of an ACEI\/ARB within 72\u00a0hours after being hospitalized. Patients were selected from the Medical Information Mart for Intensive Care IV database. We included 18,986 critically ill patients in our analysis. After propensity score matching, our final study cohort of 4974 patients consisted of patients who received early administration of an ACEI\/ARB (n\u00a0=\u00a02487) and nonusers (n\u00a0=\u00a02487). Results of logistic regression showed that early administration of an ACEI\/ARB was associated with reduced risk of in\u2010hospital mortality (odds ratio, 0.64; 95% confidence interval, 0.53\u20130.77; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and intensive care unit death (odds ratio, 0.56; 95% confidence interval, 0.45\u20130.70; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) when compared to nonusers. There was no meaningful interaction for early administration of an ACEI\/ARB versus nonusers across estimated glomerular filtration rate in outcomes. Sensitivity analysis showed there was no difference in the outcomes between early administration of ACEI and that of ARB. In this study, we found that early administration of an ACEI\/ARB was associated with a reduced risk of in\u2010hospital adverse outcomes based on renal function among critically ill patients. There was no interaction between early administration of an ACEI\/ARB and in\u2010hospital adverse outcomes across estimated glomerular filtration rate.<\/jats:p>","DOI":"10.1002\/jcph.2302","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T07:19:42Z","timestamp":1688627982000},"page":"1344-1351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Angiotensin\u2010Converting Enzyme Inhibitors\/Angiotensin Receptor Blockers on In\u2010Hospital Outcomes Based on Renal Function Among Critically Ill Patients: Findings From the Medical Information Mart for Intensive Care IV Database"],"prefix":"10.1002","volume":"63","author":[{"given":"Chong","family":"Zhang","sequence":"first","affiliation":[{"name":"The Third Central Clinical College of Tianjin Medical University Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin 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