{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:28:58Z","timestamp":1787167738754,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this research was to evaluate the efficacy of 3 ovulation induction therapies for treating infertility in patients with polycystic ovary syndrome (PCOS). In this retrospective study, we compared the success rates of 90 patients who underwent intrauterine insemination, who were randomly assigned to 1 of 3 treatment groups: letrozole (LE) + urinary gonadotropin (human menopausal gonadotropin [HMG]), clomiphene (CC) + HMG, or HMG alone. Using ultrasound scanning, we examined the number of mature follicles, ovulation rate, clinical pregnancy rate, endometrial thickness, and blood flow. When compared to the other 2 groups, the LE\u00a0+\u00a0HMG group had significantly higher levels of mature follicles, ovulation rate, clinical pregnancy rate, estradiol, and luteinizing hormone on the day of the human chorionic gonadotropin injection and endometrial receptivity (<jats:italic>P<\/jats:italic> &lt; .05). There was no statistically significant difference between the 3 groups in terms of abortion rate, ectopic pregnancy rate, or adverse reactions. In this research, we found that infertility in patients with PCOS could be effectively treated by combining LE with HMG. This protocol increased ovulation, boosted fertility, and enhanced endometrial receptivity with no increase in adverse reactions. Therefore, it may be a useful clinical approach for inducing ovulation and treating infertility in patients with PCOS.<\/jats:p>","DOI":"10.1002\/jcph.2318","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T11:31:34Z","timestamp":1690371094000},"page":"1371-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Three Ovulation Induction Therapies for Patients With Polycystic Ovary Syndrome and Infertility"],"prefix":"10.1002","volume":"63","author":[{"given":"Ting\u2010Ting","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Affiliated Hospital of Jinggangshan University Ji'an Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Fei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of Jinggangshan University Ji'an Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5683-5597","authenticated-orcid":false,"given":"Qing\u2010Mei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Affiliated Hospital of Jinggangshan University Ji'an Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.048"},{"issue":"04","key":"e_1_2_10_3_1","first-page":"468","article-title":"Effect of multi\u2010stage ovulation induction on 98 infertile patients with polycystic ovary syndrome","volume":"37","author":"Cheng ZX","year":"2016","journal-title":"Anhui Med J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05010067.x"},{"issue":"09","key":"e_1_2_10_5_1","first-page":"828","article-title":"CSRM consensus on key indicators for quality control in ART clinical operation","volume":"27","author":"Hu LL","year":"2018","journal-title":"J Reprod Med"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.024"},{"issue":"5","key":"e_1_2_10_7_1","first-page":"399","article-title":"Effect of letrozole on ovulation in polycystic ovary syndrome","volume":"25","author":"Ye LL","year":"2014","journal-title":"Chin J Clin Pharmacol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115616496"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.12.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12831"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1612358"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2014.08.004"},{"key":"e_1_2_10_13_1","first-page":"354","volume-title":"Reproductive Biology","author":"Yang ZM","year":"2005"},{"issue":"7","key":"e_1_2_10_14_1","first-page":"464","article-title":"Effects of parthenolide on estradiol\u2010synthesizing enzyme, ER isoforms and VEGF in human endometriotic stromal cells","volume":"54","author":"Song H","year":"2019","journal-title":"Chin J Obstet Gynecol"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.2318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T12:41:34Z","timestamp":1699533694000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.2318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jcph.2318"],"URL":"https:\/\/doi.org\/10.1002\/jcph.2318","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,10]]},"assertion":[{"value":"2023-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}