{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:14:47Z","timestamp":1790007287479,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Flight simulators have an essential role in aircrew training. Occasionally, symptoms of motion sickness, defined as simulator sickness, develop during these sessions. Preventive methods for motion sickness have been investigated thoroughly; however, only a few studies have examined preventive treatments for simulator sickness. The aim of this study was to examine the efficacy of scopolamine (an anticholinergic drug) compared with cinnarizine (an antihistaminic drug) for helicopter simulator sickness prevention. A validated simulator sickness questionnaire (SSQ) score was used to determine the severity of simulator sickness symptoms in this study. Preliminary SSQ scores and SSQ scores after each sortie were calculated. Each participant was given scopolamine, cinnarizine, or a placebo in a double\u2010blind randomized manner before the first sortie of each training day. Forty\u2010one helicopter pilots participated in the trial. The average age was 30.5\u00a0\u00b1\u00a07.1\u00a0years. SSQ values significantly improved from an average of 73.30 in the preliminary SSQ questionnaire to an average of 30.92 after 2\u00a0hours following the administration of cinnarizine (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.012, 95%CI 8.071\u201076.703). Scopolamine was found to be less effective than both cinnarizine and the placebo in the alleviation of simulator sickness symptoms. This study is the first to compare scopolamine with cinnarizine for simulator sickness prevention. Based on the results of this study, we recommend the use of cinnarizine over scopolamine for simulator sickness prevention.<\/jats:p>","DOI":"10.1002\/jcph.2319","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T05:00:21Z","timestamp":1690347621000},"page":"1119-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anticholinergic Versus Antihistaminic Treatment for Simulator Sickness Prevention"],"prefix":"10.1002","volume":"63","author":[{"given":"Oded","family":"Ben\u2010Ari","sequence":"first","affiliation":[{"name":"Department of Military Medicine Faculty of Medicine The Hebrew University Jerusalem Israel"},{"name":"The Israeli Air Force Aeromedical Center Tel\u2010Hashomer Ramat Gan Israel"},{"name":"Israeli Defense Forces Medical Corps Tel\u2010Hashomer Ramat Gan Israel"},{"name":"The Adelson School of Medicine Ariel University Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shani","family":"Sarfati","sequence":"additional","affiliation":[{"name":"The Israeli Air Force Aeromedical Center Tel\u2010Hashomer Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barak","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Military Medicine Faculty of Medicine The Hebrew University Jerusalem Israel"},{"name":"The Israeli Air Force Aeromedical Center Tel\u2010Hashomer Ramat Gan Israel"},{"name":"Israeli Defense Forces Medical Corps Tel\u2010Hashomer Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Assa","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical Center and Faculty of Medicine Hebrew University of Jerusalem Jerusalem 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