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We aimed to evaluate the incidence of adverse events induced by atropine in children with myopia. We performed a systematic literature search in several databases for studies published until November 2022. The incidence of adverse events induced by atropine was pooled by a common\u2010effect (fixed\u2010effect) or random\u2010effects model. Subgroup analyses were conducted according to drug doses, types of adverse events, and ethnicity. A total of 31 articles were ultimately included in the study. The overall incidence of adverse events for atropine was 5.9%, and the incidence of severe adverse events was 0.0%. The most commonly reported adverse events were photophobia (9.1%) and blurred near vision (2.9%). Other adverse events including eye irritation\/discomfort, allergic reactions, headache, stye\/chalazion, glare, and dizziness occurred in less than 1% of the patients. The incidence of atropine\u2010induced adverse events varied depending on the drug doses. A lower dose of atropine was associated with a lower incidence of adverse events. There was no significant difference in the incidence of adverse events for low\u2010dose atropine between Asian and White children. Our study suggests photophobia and blurred near vision are the most frequently reported adverse events induced by atropine. Low\u2010dose atropine is safer than moderate\u2010 and high\u2010dose atropine. Our study could provide a safe reference for ophthalmologists to prescribe atropine for myopic children.<\/jats:p>","DOI":"10.1002\/jcph.2320","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T07:58:59Z","timestamp":1690358339000},"page":"1377-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Incidence of Adverse Events Induced by Atropine in Myopic Children: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"63","author":[{"given":"Hong","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjiao","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Eye &amp; ENT Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.3563"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000677"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"891","article-title":"The effect of atropine on myopia","volume":"3","author":"Bedrossian RH","year":"1971","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(79)35455-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000932"},{"key":"e_1_2_9_8_1","unstructured":"NDA 206289 Atropine Sulfate Ophthalmic Solution USP 1%. 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