{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:47:59Z","timestamp":1780343279911,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we examined the impact of dexmedetomidine (DEX) on the effectiveness of epidural analgesia and labor outcomes. We administered different doses of DEX combined with 0.1% ropivacaine for epidural analgesia to evaluate the clinical effects and safety. To assess the effects of different concentrations of DEX in parturient women receiving epidural analgesia, we conducted a randomized double\u2010blind trial. We selected 400 parturient women and randomly assigned them to 4 groups, with 100 parturient women in each group: S0.1 (0.1\u00a0\u00b5g\/mL DEX), S0.2 (0.2\u00a0\u00b5g\/mL DEX), S0.3 (0.3\u00a0\u00b5g\/mL DEX), and a control group (0.3\u00a0\u00b5g\/mL sufentanil). Post\u2010analgesia, we recorded the Bromage score, duration of labor, method of delivery, bleeding, neonatal Apgar score, adverse reactions, and maternal satisfaction. The number of patients with a Bromage score of \u22652 and the incidence of bradycardia were higher in the S0.3 group compared with the other 3 groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), whereas the high satisfaction rate was lower in the S0.3 group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Moreover, we found that the number of times that additional patient\u2010controlled analgesia was administered was higher in the S0.1 group compared with the remaining 3 groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The control group exhibited a higher incidence of pruritus than the other 3 groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). In conclusion, when administering spinal anesthesia for the relief of labor pain, epidural analgesia with 0.1% ropivacaine combined with 0.2\u00a0\u00b5g\/mL DEX provides relatively ideal analgesic effects, higher maternal satisfaction, and reduces the incidence of pruritus, compared with the combination of 0.1% ropivacaine and 0.3\u00a0\u00b5g\/mL sufentanil.<\/jats:p>","DOI":"10.1002\/jcph.2335","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T21:39:36Z","timestamp":1691789976000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Influence of Dexmedetomidine as an Adjuvant in Intrathecal Labor Analgesia: A Multicenter Study on Efficacy and Maternal Satisfaction"],"prefix":"10.1002","volume":"64","author":[{"given":"Chengyi","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Nanning Maternal and Child Health Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1099-6624","authenticated-orcid":false,"given":"Maoling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Nanning Maternal and Child Health Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hangzhou Maternal and Child Health Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Nanning Wuming District Maternal and Child Health Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Nanning Maternal and Child Health Hospital  Nanning 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