{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:19:30Z","timestamp":1747149570167,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Randomized controlled trials have shown a higher risk of postoperative hypoxemia and delayed extubation with opioid\u2010free anesthesia (OFA), compared with opioid anesthesia. The practice of OFA is not standardized. The objective of this study is to investigate the association between the dexmedetomidine administration protocol used and the occurrence of postoperative respiratory complications. This work is a retrospective, propensity score\u2010adjusted study (inverse probability of treatment weighting) conducted between January 2019 and September 2021 in a French tertiary care university hospital, including 180 adult patients undergoing major digestive surgery. Comparison of 2 anesthesia protocols: with a continuous intravenous maintenance dose of dexmedetomidine following a bolus (group\u00a0B+M, n\u00a0=\u00a0105) or with a bolus dose alone (group\u00a0B, n\u00a0=\u00a075). The main outcome measure was a composite respiratory end point within 24\u00a0hours of surgery. There was no significant difference in the incidence of overall respiratory complications, as assessed by the primary end point. Nevertheless, there were more patients with postoperative hypercapnia in group\u00a0B+M than in group\u00a0B (16% vs 2.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). Patients in group\u00a0B+M were extubated later than patients in group\u00a0B (group\u00a0B+M, median 40\u00a0minutes, IQR 20\u201074\u00a0minutes; group\u00a0B, median 20\u00a0minutes, IQR 10\u201050\u00a0minutes; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). Our study showed negative results for the primary end point. However, data on the increased risk of postoperative hypercapnia in patients receiving a maintenance dose of dexmedetomidine are new. Other prospective randomized studies with greater power are necessary to confirm these data and to make OFA safer, by reducing the prescribed doses of dexmedetomidine.<\/jats:p>","DOI":"10.1002\/jcph.2354","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T03:44:47Z","timestamp":1695786287000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Two Dexmedetomidine Administration Strategies on the Incidence of Postoperative Respiratory Complications: A Retrospective, Inverse Probability of Treatment Weighted Study"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1817-5055","authenticated-orcid":false,"given":"Charles","family":"Baulier","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Critical Care and Perioperative Medicine Rouen University Hospital  Rouen 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