{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:36:47Z","timestamp":1792427807874,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accp1.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Voriconazole is commonly recommended as a first\u2010line therapy for invasive aspergillosis infections. Elderly patients are susceptible to infectious diseases owing to their decreased physical function and immune system. Our study aims to establish a population pharmacokinetics model for elderly patients receiving intravenous voriconazole, and to optimize dosing protocols through a simulated approach. An accurate fit to the concentration\u2013time profile of voriconazole was achieved by employing a 1\u2010compartment model featuring first\u2010order elimination. The typical clearance rate of voriconazole was found to be 3.22\u00a0L\/h, with a typical volume of distribution of 194\u00a0L. The covariate analysis revealed that albumin (ALB), gamma\u2010glutamyl transpeptidase, and direct bilirubin had significant impacts on voriconazole clearance. Additionally, body weight was found to be associated with the volume of distribution. Individualized dosing regimens were recommended for different ALB levels based on population pharmacokinetics model prediction. The proposed dosing regimens could provide a rationale for dosage individualization, improve the clinical outcomes, and minimize drug\u2010related toxicities.<\/jats:p>","DOI":"10.1002\/jcph.2357","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:54:51Z","timestamp":1695880491000},"page":"253-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Population Pharmacokinetics of Voriconazole and Dose Optimization in Elderly Chinese Patients"],"prefix":"10.1002","volume":"64","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School  Nanjing Jiangsu China"},{"name":"Nanjing Medical Center for Clinical Pharmacy  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy\uff0cChina Pharmaceutical University Nanjing Drum Tower Hospital  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5160-7855","authenticated-orcid":false,"given":"Weihong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School  Nanjing Jiangsu China"},{"name":"Nanjing Medical Center for Clinical Pharmacy  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Bureau of Statistics of the People's Republic of China: Bulletin of the seventh Census.http:\/\/www.stats.gov.cn\/sj\/sjjd\/202302\/t20230202_1896484.html2021.http:\/\/www.stats.gov.cn\/sj\/zxfb\/202302\/t20230203_1901081.html."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.09.020406"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.11.08010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106078"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2008-740ST"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw045"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106692"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00626-12"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.05.019"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00735-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-022-01196-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1126580"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000441"},{"key":"e_1_2_10_16_1","first-page":"2021","article-title":"Factors affecting voriconazole concentration to dose ratio changes according to route of administration","author":"Chen C","year":"2022","journal-title":"Eur J Hosp Pharm"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13293"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02795"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90166-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14578"},{"issue":"2","key":"e_1_2_10_21_1","first-page":"149","article-title":"Clinical hepatotoxicity associated with antifungal agents","volume":"162","author":"Kyriakidis I","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-015-0507-z"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-022-03359-2"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13431"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-013-0607-8"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2634"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1328279"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00702-11"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.04.027"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1562903"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00970-16"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw099"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000799"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03641-14"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1451"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx500203s"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.06.140"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9669431"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15495"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-020-02831-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12932"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13595"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C261"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks312"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40780-016-0044-9"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.12.024"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcph.2357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:55:17Z","timestamp":1706518517000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/jcph.2357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jcph.2357"],"URL":"https:\/\/doi.org\/10.1002\/jcph.2357","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]},"assertion":[{"value":"2023-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}